| 慢性胆道梗阻时肝脏病理变化的立体学研究 |
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| 引用本文： | 程迅生 迟彦邦. 慢性胆道梗阻时肝脏病理变化的立体学研究[J]. 中国微循环, 1998, 2(1): 28-30 |
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| 作者姓名： | 程迅生 迟彦邦 |
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| 作者单位： | 中国人民解放军第105医院!合肥230031(程迅生)，第三军医大学附属新桥医院(迟彦邦) |
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| 摘 要： | 用立体学方法测得大鼠胆总管结扎后1W、2W、3W，其汇管区周围肝窦横径较对照组明显扩张（P＜0．01），增大幅度分别为67．34％、86．26％和94．81％。单位体积肝窦表面积较对照组明显减小（P＜0．01），减小幅度分别为31．07％、32．94％和36．21％。各结扎组中，肝细胞体积比较对照组肝细胞体积比减小（P＜0．05）；肝内纤维组织体积比较对照组肝内纤维组织体积比增加（P＜0．05）；肝内小血管体积比虽较对照组肝内小血管体积比增加，但无统计学差异（P＞0．05）。本实验证实：慢性肛道梗阻后肝内分流途径是汇管区周围扩张的肝窦。
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| 关 键 词： | 胆总管梗阻 立体学 肝脏病理 |
Stereological Study of Pathological Changes of Liver in Chronic Biliary Obstruction |
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| Chen Xunshen,Chi Yanbang,. Stereological Study of Pathological Changes of Liver in Chronic Biliary Obstruction[J]. Journal of Chinese Microcirculation, 1998, 2(1): 28-30 |
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| Authors: | Chen Xunshen Chi Yanbang |
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| Affiliation: | Chen Xunshen;Chi Yanbang; (No.105 Hospital of PLA. Hefei(230031)) |
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| Abstract: | The authors found,using stereological methods.that the sinusoids of rats in peri-Portal areadialated significantly one,two or three weeks after common bile duct ligation (CBDL),compared to control (P<0.01 ),and the dialating rates were 67. 34%, 86. 26% and 94. 81 % respectively. The surface area of sinusoids per unit volume decreased significantly in all 3 CBDL groups,compared to control (P<0.01),and thedecreasing rates were 31.07%, 32. 94% and 36. 21% respectively. The volume ratios of liver cells in 3 CBDLgroups decreased and the volume ratios of intrahepatic fibrous tissue increased significantly,compared to control (P<0.05). The volume ratios of intrahepatic small vessels in 3 CBDL groups increased slightly thanthat in control,but there were not statistically significant differences among them (P>0.05). The resultsconfirmed that the intrahepatic shunts, which deve1oped after CBDL, were dialated sinusoids in peri-portalarea. |
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| Keywords: | Common bile duct obstruction Stereology Hepatic pathology |
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