人参二醇皂甙和三醇皂甙对兔纹状体ATP酶的影响

本文报道用体外给药法,观察了PDS和PTS对纹状体ATP酶(Na⁺、K⁺-ATP酶,Ca²⁺-ATP酶及M²⁺-ATP酶)的影响。结果发现PDS和PTS对Na⁺,K⁺-ATP酶都有明显的抑制作用,且随PDS和PTS浓度的高低,其抑制作用增强或减弱;对Ca²⁺-ATP酶,PDS在10^-5g/ml时有激活作用,当浓度增高到10^-3g/mL时则转为抑制,而PTS仅为抑制效应;对于Mg²⁺-ATP酶能被PDS所兴奋,而被PTS所抑制。此结果表明PDS和PTS对中枢神经系统的作用,可能与其影响脑内ATP酶有密切的内在联系。

EFFECT OF PANAXADIOL SAPONIN AND PANAXATRIOL SAPONIN ON THE ACTIVITY OF ATPase IN RABBIT STRIATUM MICROSOME

Effect of panaxadiol saponin (PDS) and panaxatriol saponin(PTS) isolated from the stem and leaves of Panaxa Ginseng on the activity of ATPase (Na~+, K~+-ATPase, Ca~(2+)-ATPase, Mg~(2+)-ATPase) in rabbit striatum microsome is. reported. The mode of inhibition of PDS and PTS. on Na~+, K~+-ATPase was atso studied. The results showed that PDS and PTS significantly inhibited the activity of Na~+, K~+-ATPase in rabbit striatum in a concentration dependent manner ahd the actions of the two saponins are similar to those of chlorpromazine.On the, other hand, PDS in a concentration of 1:10~(-5) was found to have stimulatory, action while in a concentration of 1:10~(-3) inhibitory effect on striatum microsome Ca~(2+)-ATPase. It is postulated that the effects of PDS and PTS on CNS may be related to the ATPase activity in the striatum.