| 茯苓总三萜的抗炎作用研究 |
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| 引用本文： | 汪电雷,陈卫东,徐先祥. 茯苓总三萜的抗炎作用研究[J]. 安徽医药, 2009, 13(9): 1021-1023 |
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| 作者姓名： | 汪电雷 陈卫东 徐先祥 |
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| 作者单位： | 安徽中医学院省现代中药重点实验室,安徽,合肥,230038;安徽中医学院第一附属医院药学部,安徽,合肥,230031 |
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| 基金项目： | 安徽省教育厅资助项目 |
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| 摘 要： | 目的研究茯苓总三萜对急、慢性炎症的抑制作用。方法采用二甲苯诱导的小鼠耳肿胀、冰醋酸诱导的小鼠腹腔毛细血管通透性实验、角叉菜胶诱导的大鼠足爪肿胀、棉球诱导的大鼠肉芽肿模型，观察茯苓总三萜的抗炎作用。结果茯苓总三萜（50、150、450mg·kg-1）灌胃（ig）给药对二甲苯诱导的小鼠耳肿胀和冰醋酸引起的腹腔毛细血管渗出有明显的抑制作用；能明显减轻角叉菜胶诱导的大鼠足爪肿胀、棉球诱导的大鼠肉芽肿。结论茯苓总三萜具有良好的抗炎作用。
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| 关 键 词： | 茯苓 总三萜 抗炎作用 |
Anti-inflammatory effect of triterpene acids from poria cocos |
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| WANG Dian-lei,CHEN Wei-dong,XU Xian-xiang. Anti-inflammatory effect of triterpene acids from poria cocos[J]. Anhui Medical and Pharmaceutical Journal, 2009, 13(9): 1021-1023 |
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| Authors: | WANG Dian-lei CHEN Wei-dong XU Xian-xiang |
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| Affiliation: | WANG Dian-lei1,CHEN Wei-dong1,XU Xian-xiang2(1.Key Laboratory of Modernized Chinese Materia,Anhui College of Traditional Chinese Medicine,Hefei 230038,2.Department of Pharmacy,The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Hefei 230031) |
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| Abstract: | Aim To study the anti-inflammatory effect of triterpene acids from poria cocos （TAPC）. Methods Various inflammatory models,including the swelling of ear induced by dimethyl benzene in mice,the permeability increase of blood capillary by acetic acid in mice, hind paw edema induced by carrageenin in rat and granuloma induced by cotton pellet implantation in rat were used to explore the anti-izfflammation of TAPC. Results TAPC（50,150,450 mg ~ kg-1 ,ig） could significantly inhibit the ear edema and celiac capillary permeation in mice, markedly inhibit paw edema induced by carrageenin and granuloma induced by cotton pellet in rats. Conclusion TAPC has a remarkable anti-inflammatory effect. |
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| Keywords: | triterpene acids poria cocos anti-inflammatory effects |
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