厄贝沙坦氢氯噻嗪片对高血压患者左心室肥厚动脉顺应性的影响

目的：探讨厄贝沙坦氢氯噻嗪片对高血压患者左心室肥厚、动脉顺应性的影响。方法：采用自身前后对照试验,对确诊原发性高血压的入选患者,给予口服厄贝沙坦氢氯噻嗪片,1片/d,并调整剂量或联合用药使其达到目标血压,疗程12个月。治疗前后用动态血压监测仪、彩色超声多普勒检测左室相关数据及颈动脉顺应性相关数据,并对结果进行分析。结果：治疗后血压明显下降,并达到目标血压,左心室舒张末期内径、左心室后壁与室间隔厚度显著下降（P≤0.05）,动脉顺应性指标均较治疗前有明显改善（P〈0.05）。结论：原发性高血压患者使用厄贝沙坦氢氯噻嗪片治疗12个月,可以逆转左心室肥厚,改善左室舒张功能,并能改善动脉的顺应性。

Effect of Irbesartan Hydrochlorothiazide Tablets on Left Ventricular Hypertrophy Patients with Hypertension and Arterial Compliance

Objective:To explore the effect of irbesartan hydrochlorothiazide tablets on patients with hypertension left ventricular hypertrophy,arterial compliance.Method:Before and after the adoption of self-controlled trials,Selected pairs of patients diagnosed with primary hypertension,To give oral irbesartan hydrochlorothiazide tablets,1 tablet /day,And adjust the dose or combination therapy to achieve the target blood pressure,Course of 12 months.Before and after treatment with ambulatory blood pressure monitorin...