彩色多普勒对糖尿病患者眼底血管血流动力学研究

目的:研究糖尿病患者眼底血管的血流动力学改变。方法:采用彩色多普勒技术对30例正常人和90例糖尿病患者视网膜中央动脉(CRA)、视网膜中央静脉(CRV)和眼动脉(OA)的血流参数进行检测。结果:糖尿病患者CRA血流速度较对照组降低(P<0.05),以舒张期末血流速度(Vd)降低为显著(P<0.01),阻力指数(RI)比对照组增高(P<0.05);CRV血流速度较对照组升高(P<0.05),CRA/CRV比值降低;OA收缩期峰值血流速度(Vs)和舒张期末血流速度(Vd)比对照组均降低(P<0.05),以Vd降低明显(P<0.01),RI比对照组显著增高(P<0.01)。糖尿病合并增殖性视网膜病变的患者(C组),收缩期峰值血流速度(Vs)、平均血流速度(Vmean)比糖尿病无视网膜病变患者(A组)降低(P<0.05)。结论:糖尿病患者眼底血管的血流动力学异常,对糖尿病视网膜病变的早期诊断、防治有重要意义。

A study on hemodynamics of eye fundus blood vessel in patients with diabetes mellitus with CDFI

Objective:To study the changes of hemodynamics of eye fundus blood vessel in patients with diabetes mellitus.Methods:With color Doppler flow imaging(CDFI),blood flow parameters of central retinal artery(CRA),central retinal vein(CRV)and ophthalmic artery(OA)were assessed for 30 normal persons and 90 cases of diabetes mellitus.Results:CDFI showed that blood flow velocity of CRA in patient were lower than that of normal subjects(P<0.05),the end diastolic velocity(Vd)were prominent(P<0.01),while the resistance index(RI)of CRA in cases were higher than that of the control group(P<0.05),blood flow velocity of CRV in cases were higher than that of normal control group(P<0.05),the proportion of velocity of CRA to CRV were lower than control group;The peak systolic velocity(Vs)and the end diastolic velocity(Vd)of OA were lower than that of the control group(P<0.05),Vd were prominent(P<0.01),RI of OA in cases were obviously higher than that of control group(P<0.01).The peak systolic velocity(Vs)and the mean-enveloped velocity(Vmean)in cases(C group) with diabetic retinopathy in proliferative phase were lower than that of cases(A group)with diabetes but without retinopathy(P<0.05).Conclusion:CDFI can detect hemodynamic abnormality of eye fundus blood vessel in patients with diabetes mellitus,this has important value in early diagnosis,prevention and cure in diabetic retinopathy.