18F-FDG PET/CT诊断非小细胞肺癌纵隔淋巴结转移

目的 探讨¹⁸F-FDG PET/CT诊断非小细胞肺癌（NSCLC）纵隔淋巴结转移的价值。方法 回顾性分析130例初诊NSCLC患者（337个纵隔淋巴结）术前PET/CT资料，与术后病理结果相对照，评价PET/CT诊断NSCLC纵隔淋巴结转移的灵敏度、特异度及准确率。结果 以患者为观察单位，PET/CT发现纵隔淋巴结转移66例，无纵隔淋巴结转移64例，灵敏度79.41%（54/68），特异度80.65%（50/62），准确率80.00%（104/130），阳性预测值81.82%（54/66），阴性预测值78.13%（50/64）；以淋巴结数为单位，PET/CT诊断纵隔淋巴结转移125个，非纵隔淋巴结212个，PET/CT诊断纵隔淋巴结转移的灵敏度74.42%（96/129），特异度86.06%（179/208），准确率81.60%（275/337），阳性预测值76.80%（96/125），阴性预测值84.43%（179/212）。PET/CT结果与病理结果比较差异无统计学意义。结论 ¹⁸F-FDG PET/CT诊断NSCLC纵隔淋巴结转移具有较高价值。

18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer

Objective To explore the value of ¹⁸F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer (NSCLC). Methods A total of 130 histologically proved NSCLC patients with 337 nodal stations without any therapy who underwent ¹⁸F-FDG PET/CT were reviewed. Pathologic nodal classifications were used as the final standards to evaluate the sensitivity, specificity and accuracy rate of PET/CT. Results Taking patients as research object, PET/CT showed mediastinal lymph node metastasis in 66 patients, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 79.41% (54/68), 80.65% (50/62), 80.00% (104/130), 81.82% (54/66) and 78.13% (50/64), respectively. Taking lymph node as research object, 125 lymph nodes were diagnosed positive, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 74.42% (96/129), 86.06% (179/208), 81.60% (275/337), 76.80% (96/125) and 84.43% (179/212), respectively. There was no statistical difference between results of PET/CT and pathology. Conclusion ¹⁸F-FDG PET/CT has high diagnostic value for mediastinal lymph node metastasis from NSCLC.