Nerve Growth Factor Immunoreactivity of Mast Cells in Acute Involuted Human Thymus |
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Authors: | Tsvetana Marinova Stanislav Philipov Luigi Aloe |
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Institution: | (1) Department of Biology, Medical Faculty, Medical University, 2 Zdrave Street, BG-1431 Sofia, Bulgaria;(2) Department of General and Clinical Pathology, Medical University, Sofia, Bulgaria;(3) Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy |
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Abstract: | The acute involution of the thymus is induced by either exogenous or endogenous factors, including some infections (infection
type involution). The present study was focused on both detection and immunocytochemical analysis of NGF immunopositive mast
cells in child thymus with acute infection-induced involution. Autopsy thymus specimens from children with infection diseases
(Sepsis, Encephalomyelitis, Varicella) were examined at light and electron microscopic level and compared to normal infantile
thymuses. We observed a redistribution of NGF immunopositive mast cells in infection-affected child thymus, which lobular
architecture was collapsed. A positive correlation between the degree of the involutive changes, increased distribution and
enhanced NGF immunoreactivity of mast cells was defined. The possible involvement of NGF immunopositive mast cells in the
process of acute thymus involution is discussed. |
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Keywords: | NGF immunoreactivity mast cells thymus |
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