The Screening of Patients with Extrahepatic Biliary Atresia by Measuring Total Bile Acids Absoredin Dried Blood Spots |
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| Authors: | Akira Matsui MD Takako Fujimoto MD Yoshie Takazawa MD Yasuo Kasano MD Mariko Okaniwa MD Shigehiko Kamoshita MD |
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| Institution: | Department of Paediatrics, Jichi Medical School, Tochigi, Ibraki, Japan;*Department of Paediatrics, Ibaraki Prefectural Hospital, Ibraki, Japan |
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| Abstract: | The efficency was assessed of the screening for extrahepatic biliary atresia by measuring total bile acids absorbed in dried blood spots at around 5 days of age. When the cut-off level was 54.0 μmol/l, the sensitivity, the specificty and the efficiency of the screening test were 87.9%, 93.9% and 93.9% respectively. The case-finding rate was 0.009% in this type of screening which was three times as many as an early case-finding rate by population screening. These results suggest that teh efficiency of this screening is acceptable. |
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| Keywords: | EHBA–extrahepatic biliary atresia TBA–total bile acids |
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