| 乳腺浸润性导管癌中COX-2、MMP-2的表达与细胞增殖的关系 |
| |
| 引用本文： | 邱东民,周士福,蔡凤林,时伟锋,金留根. 乳腺浸润性导管癌中COX-2、MMP-2的表达与细胞增殖的关系[J]. 苏州大学学报(自然科学版), 2008, 28(4) |
| |
| 作者姓名： | 邱东民 周士福 蔡凤林 时伟锋 金留根 |
| |
| 作者单位： | [1]无锡卫生高等职业技术学校,江苏无锡214028 [2]苏州大学附属第四医院普通肿瘤外科,江苏无锡214062 |
| |
| 摘 要： | 目的探讨环氧化酶-2（COX-2）和基质金属蛋白酶-2（MMP-2）蛋白在乳腺浸润性导管癌组织中的表达及其与细胞增殖的关系。方法应用免疫组织化学法检测52例乳腺浸润性导管癌组织中COX-2、MMP-2和Ki-67蛋白的表达情况。结果乳腺浸润性导管癌组织中COX-2的阳性表达率为57．7％（30／52），MMP-2的阳性表达率为82．7％（43／52），在乳腺浸润性导管癌组织中COX-2、MMP-2蛋白的表达之间存在显著正相关（r=0．498，P〈0．01）。COX-2、MMP-2阳性组Ki-67指数明显高于COX-2、MMP-2阴性组，差异有统计学意义（P〈0．05）。结论乳腺浸润性导管癌组织中存在COX-2、MMP-2的高表达。COX-2蛋白可通过诱导MMP-2蛋白的表达上调，增加乳腺癌细胞的侵袭力，并促进肿瘤细胞增殖，从而成为其促进乳腺癌浸润、转移的因素之一。
|
| 关 键 词： | 乳腺癌 环氧化酶-2 基质金属蛋白酶-2 Ki-67 |
Expression of COX-2 and MMP-2 in Invasive Ductal Carcinoma of Breast and Its Relationship with Cell Proliferation |
| |
| QIU Dong-min,ZHOU Shi-fu,CAI Feng-lin,SHI Wei-feng,JIN Liu-gen. Expression of COX-2 and MMP-2 in Invasive Ductal Carcinoma of Breast and Its Relationship with Cell Proliferation[J]. Suzhou University Journal of Medical Science, 2008, 28(4) |
| |
| Authors: | QIU Dong-min ZHOU Shi-fu CAI Feng-lin SHI Wei-feng JIN Liu-gen |
| |
| Affiliation: | QIU Dong-min1,ZHOU Shi-fu2,CAI Feng-lin2,SHI Wei-feng2,JIN Liu-gen2(1.Wuxi Higher Health Vocational Technology School,Jiangsu Wuxi 214028,China,2.Dept of Surgical Oncology,the Fourth Hospital Affiliated to Suzhou University,Jiangsu Wuxi 214062,China) |
| |
| Abstract: | Objective To study the expression of cyclooxygenase-2(COX-2) and matrix metallproteinase-2(MMP-2) in invasive ductal carcinoma of breast and its relationship with cell proliferation.Methods Expression of COX-2,MMP-2 and Ki-67 was detected in 52 cases of breast cancer tissue by immunohistochemistry.Results The positive COX-2 expression was 57.7% in invasive ductal carcinoma of breast,and the positive MMP-2 was 82.7%.There was a significant correlation between the expressions of COX-2 and MMP-2 in breast canc... |
| |
| Keywords: | Ki-67 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
