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Serum TNF-alpha and free radical scavengers in neonatal septicemia |
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| Authors: | Seema Ramesh Kumar R. N. Mandal Anita Tandon V. S. Randhawa G. Mehta S. Batra G. N. Ray A. K. Kapoor |
| Affiliation: | (1) Department of Pediatrics, Kalawati Saron Children’s Hospital and Lady Hardinge Medical College, New Delhi;(2) Department of Pediatrics, Kalawati Saron Children’s Hospital and Lady Hardinge Medical College, New Delhi;(3) Department of Pediatrics, Kalawati Saron Children’s Hospital and Lady Hardinge Medical College, New Delhi;(4) Department of Pediatrics, Kalawati Saron Children’s Hospital and Lady Hardinge Medical College, New Delhi;(5) Department of Microbiology, Kalawati Saron Children’s Hospital and Lady Hardinge Medical College, New Delhi;(6) Department of Microbiology, Kalawati Saron Children’s Hospital and Lady Hardinge Medical College, New Delhi;(7) Department of Biochemistry, Kalawati Saron Children’s Hospital and Lady Hardinge Medical College, New Delhi;(8) Department of Biochemistry, Kalawati Saron Children’s Hospital and Lady Hardinge Medical College, New Delhi;(9) Department of Biochemistry, Kalawati Saron Children’s Hospital and Lady Hardinge Medical College, New Delhi;(10) H.No. 7, Old Registrar Block, Lady Hardinge Medical College Campus, 110 001 New Delhi |
| Abstract: | Tumor necrosis factor-alpha (TNF-alpha) and free radicals have been implicated in the pathogenesis of neonatal septicemia and its complications. This case control study was conducted between November 1996 to July 1997 to determine the levels of TNF-alpha and free radical scavengers viz. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) in the serum of 30 septic neonates and 20 healthy controls. Patients with neonatal sepsis registered significantly higher levels of TNF-alpha, SOD and GPX in comparison to controls (p < 0.05). The neonates with septic shock had five fold increase in TNF-alpha levels (2262 ±605.8 pg/ml) as compared to those without shock (738.8 ±28.8 pg/ml). There was no statistically significant difference in levels of antioxidant enzymes between neonates with shock and without shock. The levels of TNF-alpha and antioxidant enzymes were not affected by the type of organism isolated in blood culture. |
| Keywords: | Neonatal sepsis Tumor necrosis factor Free radicals Antioxidant enzymes |
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