Human colonic (Na++K+)-ATPase and specific ouabain binding are not influenced by lipoxygenase products or superoxide radicals |
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| Authors: | H. Allgayer W. Kruis E. Erdmann |
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| Affiliation: | (1) Medizinische Klinik II, Klinikum Großhadern, Universität München, Germany;(2) Medizinische Klinik I, Klinikum Großhadern, Universität München, Germany;(3) Klinikum Karlsruhe, Moltkestr. 14, D-7500 Karlsruhe |
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| Abstract: | Summary The effects of lipoxygenase products (5-, 12-, 15-HETE, LTB4) and superoxide radicals on human colonic (Na++K+)-ATPase and specific ouabain binding were measured. No significant inhibition in concentrations up to 3 × 10–5M was observed. The results are discussed with regard to a possible role of lipoxygenase products and radicals in the pathogenesis of water and electrolyte disturbances in various diarrheal states including inflammatory bowel disease.Abbrevations IBD Inflammatory bowel disease - HETE Hydroxytetraenoic acid - LTB4 Leukotriene B4Supported by DFG (Er 65/4-4) |
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| Keywords: | Colonic (Na++K+)-ATPase Specific ouabain binding Lipoxygenase pathway products Superoxide radicals |
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