IgA、IgM、IgD和IgE在卵巢上皮性癌中的表达

目的：探讨免疫球蛋白IgA、IgM、IgD、IgE在卵巢上皮性癌中的表达及表达强度与卵巢上皮性癌病理分级的相关性。方法：应用免疫组织化学法检测卵巢上皮性癌组织芯片(含177例卵巢上皮性癌)、50例卵巢良性肿瘤上皮组织中IgA、IgM、IgD、IgE的表达水平。 结果：卵巢上皮性癌组织中IgA、IgM、IgD、IgE的表达水平均明显高于卵巢良性肿瘤上皮组织 (P<0.001)；卵巢上皮性癌病理分级与IgA、IgM、IgD和IgE的表达强度均呈正相关(r=0.422，P<0.001；r=0.460，P<0.001；r=0.458，P<0.001；r=0.593，P<0.001)即病理分级越高，IgA、IgM、IgD和IgE表达越强。结论:IgA、IgM、IgD、IgE在卵巢上皮性癌组织中高表达；IgA、IgM、IgD、IgE在卵巢上皮性癌组织中的异常表达提示与肿瘤的发生、发展密切相关。

Expressions of IgA, IgM, IgD and IgE in ovarian epithelial carcinoma

Objective To explore the expressions of IgA,IgM,IgD,IgE in ovarian epithelial carcinoma and their correlations with pathological grades of ovarian epithelial carcinoma.Methods The expressions of IgA,IgM,IgD,IgE in ovarian epithelial carcinoma tissue microarrays (including 177 cases of ovarian epithelial carcinoma)and 50 cases of ovarian benign tumor tissues were detected by immunohistochemistry. Results The expressions of IgA,IgM,IgD,IgE in ovarian epithelial carcinoma tissues were significant higher than those in ovarian benign tumor epithelial tissues (P<0.001). In ovarian epithelial carcinoma there were significant positive correlation between pathological grades and the expressions of IgA,IgM,IgD and IgE(r =0.422,P<0.001;r =0.460,P<0.001);r =0.458,P<0.001;r =0.593,P<0.001), the expressions of IgA,IgM,IgD and IgE were more stronger with raising of pathological grades.Conclusion IgA,IgM,IgD,IgE express highly in ovarian epithelial carcinoma;the abnormal expressions of IgA,IgM,IgD,IgE in ovarian epithelial carcinoma indicate that they are related to the occurrence and development of ovarian epithelial carcinoma.