艾灸气海、关元穴治疗慢性疲劳综合征的临床疗效及其对大鼠免疫功能的影响

目的 探讨艾灸气海、关元穴治疗慢性疲劳综合征(CFS)的临床疗效及其对大鼠免疫功能的影响.方法 收集60例CFS患者,随机分为艾灸组和对照组各30例,艾灸组给予艾灸气海、关元穴,对照组给予口服多维元素片,比较两组治疗前后疲劳量表-14、疲劳评定量表、焦虑自评量表(SAS)得分及IgA、IgM、IgG、C3、C4水平.另将36只大鼠随机分为对照组、模型组和观察组,每组12只.以复合应激法建立模型组和观察组大鼠CFS模型,成模后艾灸观察组大鼠气海、关元穴,比较干预后3组大鼠的IgA、IgM、IgG、C3、C4水平.结果 治疗后对照组及艾灸组患者疲劳量表-14、疲劳评定量表、SAS评分均较前降低,且艾灸组各评分均低于对照组(均P<0.05).治疗后艾灸组IgG、IgA、C4水平均较治疗前升高,其中IgG、C4高于对照组(均P<0.05).艾灸干预后,模型组大鼠IgA、IgM、IgG、C3、C4水平低于对照组,而观察组以上指标高于模型组(均P<0.05).结论 艾灸气海、关元穴可改善CFS患者的疲劳、焦虑状态及免疫力与CFS大鼠的免疫功能.

Clinical efficacy of moxibustion at Qihai and Guanyuan acupoints for treatment of chronic fatigue syndromes and its influence on immune function of rats

Objective To investigate the clinical efficacy of moxibustion at Qihai and Guanyuan acupoints for the treatment of chronic fatigue syndromes ( CFS) and its influence on immune function of rats .Methods Sixty patients with CFS were randomly assigned to moxibustion group or control group , with 30 cases in each group .The moxibustion group received moxibustion at Qihai and Guanyuan acupoints,while the control group was given oral Multivitamin Formula with Minerals .The scores of Fatigue Scale-14,Fatigue Rating Scale and Self-Rating Anxiety Scale(SAS),and the levels of IgA,IgM,IgG,C3 and C4 were compared between the two groups before and after treatment.Another 36 rats were randomly divided into control group ,model group and observation group ,with 12 rats in each group.Multiple stress method was used to establish the rat model of CFS in the model group and observation group .After successful modeling ,the rats in the observation group were given moxibustion at Qihai and Guanyuan acupoints .After intervention,the levels of IgA,IgM,IgG,C3 and C4 were compared among the three groups .Results After treatment,the scores of Fatigue Scale-14,Fatigue Rating Scale and SAS of patients in the control group and moxibustion group decreased compared to the scores before treatment ,and the scores in the moxibustion group were all lower than those in the control group(all P<0.05).In the moxibustion group,the levels of IgG,IgA and C4 after treatment increased compared to the levels before treatment ,and the levels of IgG and C4 were higher than those in the control group ( all P<0.05).After intervention of moxibustion,the levels of IgA,IgM,IgG,C3 and C4 in the model group were lower than those in the control group ,and the levels of the indexes above in the observation group were higher than those in the model group (all P<0.05).Conclusion Moxibustion at Qihai and Guanyuan acupoints can improve the immune function of rats with CFS as well as improve the fatigue,anxiety states and immunity of patients with CFS.