不同麻醉方式在大鼠头颈部MRI检查中的效果比较

目的 比较不同麻醉方式在大鼠头颈部MRI检查过程中的麻醉效果.方法 将18只SD大鼠随机分成A、B、C 3组各6只,分别采用水合氯醛腹腔注射、氯胺酮腹腔注射、氯胺酮肌肉注射进行麻醉,麻醉完成后均行MRI扫描,比较3组的麻醉起效时间、持续时间、麻醉效果、大鼠死亡情况.结果 B组、C组、A组的麻醉起效时间依次缩短(P<0.05);A组的麻醉持续时间均长于B组及C组(P<0.05),但B组与C组间比较,差异无统计学意义(P>0.05).A组及C组所有大鼠均麻醉成功且MRI图像质量合格,B组2只大鼠麻醉失败,1只大鼠MRI图像质量不合格;A组2只大鼠MRI扫描后死亡,B组及C组均无大鼠死亡.结论 综合考虑麻醉时间、效果及安全性等因素,氯胺酮肌肉注射的麻醉效果较水合氯醛或氯胺酮腹腔注射更为理想,是可供选择的大鼠MRI检查的麻醉方法.

Comparison of efficacy among different anesthetic methods for MRI examination of head and neck in rats

Objective To compare the anesthetic efficacy among different anesthetic methods for MRI examination of head and neck in rats .Methods Eighteen SD rats were randomly divided into group A ,group B and group C ,with 6 rats in each group .Anesthesia using intraperitoneal injection of chloral hydrate ,intraperitoneal injection of ketamine ,intramuscular injection of ketamine were performed in group A,group B and group C respectively .MRI was conducted in all rats after anesthesia was finished .The time of anesthetic onset , duration of anesthesia ,anesthetic efficacy and death of rats were compared among the three groups .Results The time of anesthetic onset was shortened in the order of group B,group C and group A(P<0.05).The duration of anesthesia was longer in group A compared to group B or C(P<0.05),but no statistical difference was found between group B and group C(P>0.05).Successful anesthesia and qualified quality of MRI image were observed in all rats in group A and group B .In group B,unsuccessful anesthesia was found in two rats and the quality of MRI image was unqualified in one rat .Two rats in group A died after MRI examination ,and no death occurred in group B or group C . Conclusion Considering anesthetic time , efficacy and safety , intramuscular injection of ketamine achieves a better anesthetic efficacy compared to intraperitoneal injection of chloral hydrate or ketamine ,and is an optional anesthetic approach for MRI in rats .