骨桥蛋白在糖尿病肾病中作用的研究进展

骨桥蛋白是一种具有细胞粘附和信号转导功能的分泌型磷蛋白,研究发现它在糖尿病肾病中起重要作用。高糖和肾素血管紧张素系统等因素可以引起肾脏骨桥蛋白表达升高。骨桥蛋白主要通过巨噬细胞趋化、蛋白尿形成和肾脏纤维化等机制促进糖尿病肾病的发生和进展,抑制骨桥蛋白则可以改善糖尿病肾病。此外,骨桥蛋白基因多态性还与糖尿病肾病易感性相关。作为糖尿病肾病诊断和治疗的重要靶点,对骨桥蛋白的深入研究有助于阐明糖尿病肾病的发病机制,开发新的生物学诊断标记物和治疗药物。

Research progress of the role of osteopontin in diabetic nephropathy

Osteopontin is a kind of secreted phosphoprotein with function of cell adhesion and signal transduction.It has been reported to play an important role in diabetic nephropathy.High glucose level and the renin angiotensin system can cause elevated osteopontin expression in kidney.Osteopontin promotes the occurrence and progress of diabetic nephropathy mainly through mechanisms such as macrophage chemotaxis,proteinuria and renal fibrosis;and inhibition of osteopontin can improve diabetic nephropathy.In addition,genetic polymorphism of osteopontin is also associated with susceptibility to diabetic nephropathy.As an important target in the diagnosis and treatment of diabetic nephropathy,in-depth study of osteopontin can contribute to the clarification of diabetic nephropathy pathogenesis and the development of new diagnostic biomarkers and therapeutic drugs.