不同药物治疗特发性高催乳素血症患者的临床效果比较

目的 比较甲磺酸-α-二氢麦角隐亭及甲磺酸溴隐亭治疗特发性高催乳素血症(HPRL)的临床效果.方法 选择特发性HPRL女性患者42例,随机分为观察组和对照组,每组21例,分别给予甲磺酸-α-二氢麦角隐亭片、甲磺酸溴隐亭口服,疗程为6个月.比较两组治疗前及治疗后30、60、90、120、150、180 d时血清催乳素水平、患者月经和溢乳恢复正常率以及不良反应发生率.结果 两组血清催乳素水平均随治疗时间延长而下降(P<0.05),但在各时间点两组血清催乳素水平比较,差异无统计学意义(P>0.05).治疗后不同时间点两组月经正常、无溢乳患者比例比较,差异均无统计学意义(P>0.05).治疗过程中,观察组恶心、呕吐、头晕发生率低于对照组(P<0.05).结论 甲磺酸溴隐亭与甲磺酸-α-二氢麦角隐亭片治疗特发性HPRL均有效,但是甲磺酸-α-二氢麦角隐亭片不良反应发生率较低.

Comparison of clinical efficacy between different medicines for idiopathic hyperprolactinemia

Objective To compare the clinical efficacy between dihydro-α-ergocryptine and bromocriptine methanesulfonate for idiopathic hyperprolactinemia ( HPRL ) .Methods Forty-two female patients with idiopathic HPRL were recruited and were randomly divided into observation group and control group ,with 21cases in each group .The observation group and the control group were given oral dihydro-α-ergocryptine and bromocriptine methanesulfonate respectively .The treatment lasted for 6 months.Before treatment and at 30,60, 90,120,150 and 180days after treatment ,the serum prolactin level,rates of normal menstruation and non galactorrhea ,and incidence rate of side effects were compared between the two groups .Results The serum prolactin levels decreased with the increasing therapeutic time in both groups(P<0.05),but there was no significant difference in the serum prolactin level between the two groups at any time point (P>0.05).There were no significant differences in the proportion of normal menstruation or of non galactorrhea between the two groups at any time point after treatment(P>0.05).The incidence rates of nausea ,vomiting and dizziness in the observation group were lower than those in the control group during the treatment (P<0.05).Conclusion Both of dihydro-α-ergocryptine and bromocriptine methanesulfonate have effects on idiopathic HPRL ,but dihydro-α-ergocryptine has a lower incidence rate of side effects .