四环素骨诱导活性材料整复牙槽缺损的实验研究

目的将盐酸四环素处理的人离体非功能牙块用于诱导骨再生技术中，观察和比较其对牙槽骨再生修复的影响。方法拔除大鼠第一磨牙近中根做人工牙槽缺损。置入盐酸四环素处理的离体人牙块，以盐酸处理的离体人牙块为阳性对照，未做任何处理的离体人牙块为阴性对照。不同时期取材做组织观察和评价。结果四环素处理组炎症反应小，早期成骨明显。中晚期成骨量明显高于对照组。结论盐酸四环素处理的人离体非功能牙块有抑制骨吸收，诱导、促进牙槽骨再生等作用。

Experimental study on repairing the defect in alveolar bone with tetracycline activated materials for bone guide

Objective:The effect on alveolar bone regeneration and repair was observed and compared with guide bone regeneration technique -isolated human dentin blocks treated with tetracycline-HCL.Methods:The first molar mesial roots of rats were extracted as defects in alveolar bone and the isolated human dentin blocks treated with tetracycline-HCL as positive control and and untreated with anything as negative control were implanted the defect sites for histologic observation and evaluation at the different periods.Results:There is less inflammatory (in tetracycline treatment groups than control at early stages and they showed marked osteaogenesis),but the osteogenic quantity is larger than control groups at middle and late stages. Conclusion:The isolated teeth blocks treated with tetracycline HCL have actions on inhibiting bone resorption, and promoting alveolar bone generation.