维生素C对急性心肌梗死患者氧化代谢的影响

为评价抗氧化剂维生素Ｃ对急性心肌梗死患者氧化代谢指标的影响。将３０例急性心肌梗死患者随机分成常规治疗疗组和维生素Ｃ治疗组，分别予以急性心肌梗死的常规治疗和急性心肌梗死的常规治疗基础上加用维生素Ｃ，每天２克，静脉滴注，共用７天。分别测定两组患者治疗前，治疗第３天及治疗第７天的中性粒细胞化学发光参数，血清肌酸磷酸激酶活性和血浆丙二醛浓度等氧化损伤指标，并测定血浆谷胱甘肽过氧化物酶和超氧化物歧化酶活性抗

Supplementation with Vitamin C Suppresses Polymorphonuclear Leukocyte Oxygen Free Radical Production in Patients with Acute Myocardial Infarction

Aim To evaluate the preventive effect of vitamin C ,a potent free radical scavenger, on the markers of polymorphonuclear leukocyte (PMN) oxygen free radical (OFR)production, lipid peroxidation and defenses against oxidative stress in patients with acute myocardial infarction (AMI). Methods 30 patients with AMI were randomized to receive either conventional treatment only (control group, n=13) or conventional treatment supplemented with vitamin C infusion (vitamin C group,n=17), 2 g per day, for 7 days. All measurements were performed before treatment, on the 3rd and 7th day after been hospitalized. The PMN OFR production was assayed by a convenient and sensitive method named as polymorphonuclear leukocyte chemiluminescence (PMN-CL). The plasma lipid peroxides concentration measured as malondialdehyde (MDA), activities of superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) were estimated by chemical measurement. Meanwhile, serum CK activity and ECG were also monitored. Results Parameters of PMN-CL decreased significantly in vitamin C group on the 7th day compared with that in controls. Plasma MDA concentration decreased significantly on the 7th day and plasma activity of SOD increased more quickly on the 3rd and 7th day in vitamin C group than that in controls, however, it showed no salutary effects of vitamin C on CK and GSHPx activities in vitamin C group. Arrhythmia occurre less often in vitamin C group than in controls on the 7th day. Conclusions Supplementation with vitamin C may suppress PMN OFR production, decrease the levels of lipid peroxide, increase the plasma activity of antioxidative enzymatic system, and could be beneficial in preventing complications in such patients.