银杏叶提取物治疗慢性乙型肝炎肝纤维化病人32例

目的：探讨银杏叶提取物(GbE761)对慢性乙型肝炎病人肝组织纤维化的影响。方法：将60例慢性乙型肝炎病人分为GbE761治疗组32例,年龄(34±s 13)a,16～55 a及对照组28例,年龄(34±14)a,17～57a,对照组给予常规治疗,治疗组给予常规治疗加GbE761 20 mL,静脉滴注,每日1次,共4 wk,治疗前后分别检测肝功能、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)、透明质酸(HA)、层黏蛋白(LN)和转化生长因子β_1(TGF-β_1)。治疗组中5例分别于治疗前后进行肝活检术并行病理组织学检查。结果：治疗后2组的肝功能水平均较治疗前显著好转,但2组比较无差异(P>0．05)。治疗组治疗后PCⅢ,CⅣ,HA,LN及TGF-β_1水平分别下降(139±65)μg·L~(-1),(90±41)μg·L~(-1),(84±51)μg·L~(-1),(93±33)μg·L~(-1),(27±7)μg·L~(-1)(P<0．01),而对照组PCⅢ,CⅣ,HA,LN及TGF-β_1水平无明显变化(P>0．05)。治疗组5例肝活检证实,治疗后肝脏纤维化程度减轻,细胞损伤减轻。结论：GbE761对慢性乙型肝炎有显著的抗肝纤维化作用。

Study of Ginkgo biloba extract in treatment of 32 patients with liver fibrosis due to chronic hepatitis B

AIM:To evaluate the effects of Ginkgo b iloba extract (GbE761) on liver fibrosis in patients with chronic hepatitis B.METHODS:Sixty patients with chronic hepatitis B were divided into two groups: treatment group (n=32) and control group (n=28).All were under common treatment of protecting liver and the former added with GbE761 20mL,iv drip qd.The course of treatment for both groups was 4 wk.Liver func- tions,serum precollagen typeⅢ,Ⅳ-type collagen,hyaluronate (HA),laminin (LN) and transforming growth factor-β_1 (TGF-β_1) levels were measured before and after the treatment.And five patients of the treatment group were furthermore taken liver biopsy before and after the treatment.Pathological changes of liver collagen,reticu- lar fibrous tissue were detected by HE staining.RESULTS:After treatment,the indexes of liver function showed obvious improvement in both groups,and there were no significant differences between the two groups. Serum precollagen typeⅢ,Ⅳ-type collagen,hyalnronate (HA),laminin (LN) levels and plasma TGF-β_1 lev- els in the treatment group decreased by (139±s 65)μg·L~(-1),(90±41)μg·L~(-1),(84±51)μg·L~(-1),(93±33)μg·L~(-1),(27±7)μg·L~(-1)(P＜0.01) respectively after the treatment,but no difference was shown in those of the control group (P＞0.05).Collagen fibrous proliferation of five patients lessened in the treatment group.CONCLUSION :GbE761 possesses significant role of anti-fibrosis on liver in patients with chronic hep- atitis B.