肠道微生态失衡致非酒精性脂肪性肝病发病机制的研究进展

非酒精性脂肪性肝病（NAFLD）已成为一种常见的慢性肝病。近年肠道微生态失衡致NAFLD发病的机制研究已成为一个新的热点。国内外文献已报道相关发病机制可能包括干扰代谢、促进胰岛素抵抗、产生毒性代谢产物、增加肠壁通透性、激活肠道免疫、加重肝脏脂质氧化和氧化应激、激活肝脏免疫炎症损伤和肝纤维化等。而NAFLD发展到一定阶段后又可反过来影响肠道微生态，形成恶性循环。本文就肠道微生态失衡致NAFLD发病机制的研究进展作一综述。

Advances in Study on Role of Intestinal Microflora Imbalance in the Pathogenesis of Non-alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease （NAFLD） has become a common liver disease. Role of intestinal microflora imbalance in the pathogenesis of NAFLD has become a new research hotspot. The pathogenesis of NAFLD reported in domestic and abroad literatures includes： metabolism interference, promoting of insulin resistance, production of toxic metabolites, increase of intestinal permeability, activation of intestinal immune response, aggravating of liver lipid oxidation and oxidative stress, activation of immuno-inflammatory liver damage and liver fibrosis. When NAFLD develops into a certain stage, it can in turn affect the intestinal microflora, thus forming a vicious cycle. This article reviewed the advances in study on role of intestinal microflora imbalance in the pathogenesis of NAFLD.