| 苄普地尔消退L－甲状腺素诱发的大鼠心肌肥厚及其质膜Ca~（2＋），Mg~（2＋ |
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| 引用本文： | 陈丁丁,储永新,戴德哉.苄普地尔消退L－甲状腺素诱发的大鼠心肌肥厚及其质膜Ca~（2＋），Mg~（2＋[J].中国药理学与毒理学杂志,1995(3). |
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| 作者姓名： | 陈丁丁 储永新 戴德哉 |
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| 作者单位： | 中国药科大学药理学研究室 |
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| 摘 要： | 研究了苄普地尔对Ｌ－甲状腺素（１ｍｇ·ｋｇ－１·ｄ－１×７ｄ）诱发的大鼠心肌肥厚和心肌质膜Ｃａ２＋，Ｍｇ２＋－ＡＴＰ酶活力增高的影响，经苄普地尔１０或２０ｍｇ·ｋｇ－１·ｄ－１ｐｏ治疗３ｄ后，心肌肥厚及其升高的Ｃａ２＋，Ｍｇ２＿－ＡＴＰ酶活力和Ｖｍａｘ均降至正常，但甲状腺素引起的该酶对ＡＴＰ的亲和力降低未被苄普地尔改变。苄普地尔组左心室蛋白质含量较未治疗组亦显著减少，但未恢复至正常。结论：苄普地尔消退Ｌ－甲状腺素诱发的大鼠心肌肥厚，心肌Ｃａ２＋，Ｍｇ２＋－ＡＴＰ酶活力增高和蛋白质生物合成的增加。
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| 关 键 词： | 钙通道阻滞剂 苄普地尔 肥厚，心肌 腺苷三磷酸酶类 甲状腺素 质膜 普萘洛尔 |
Bepridil reverses cardiac hypertrophy and elevated sarcolemmalCa2 , Mg2 -ATPase activity induced byL-thyroxine in rats |
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| CHEN Ding-Ding, CHU Yong-Xin, DAI De-Zai.Bepridil reverses cardiac hypertrophy and elevated sarcolemmalCa2 , Mg2 -ATPase activity induced byL-thyroxine in rats[J].Chinese Journal of Pharmacology and Toxicology,1995(3). |
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| Authors: | CHEN Ding-Ding CHU Yong-Xin DAI De-Zai |
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| Abstract: | The effects of bepridil (Bep) oncardiac hypertrophy and the elevated activity ofCa2+,Mg2+-ATPase derived from myocardialsarcolemma induced by Lthyroxine (Thy) were stu-died in rats. After treatment with Bep 10 or 20 mg·kg-1· d-1 po for 3 d, the cardiac hypertrophy, ele-vated Ca2+, Mg2+-ATPase activity and Vmax inducedby Thy 1mg · kg-1 · d-1 ip for 7 d were reduced tonomal while the decreased affinity of the enzyme toATP remained unchange. In addition, the incrcasedcontent of left ventricular protein was alsosignificantly decreased by Bep treatment. It is con-cluded that Bep could reverse the cardiachypertrophy, elevated myocardial Ca2+,Mg2+-ATPase activity and increased protein biosynthesis in-duced by Thy in rats. |
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| Keywords: | calcium channel blockers bepridil hypertrophy myocardium adenosine triphosphatase thyroxine sarcolemma propranolol |
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