乙肝血清标志物-前S1抗原的临床意义

目的探讨乙肝病毒前-S1抗原与乙肝血清标记HBeAg、HBV-DNA的相互关系,了解乙肝病毒感染者血清前S1抗原的临床意义。方法双抗体夹心ELISA法测定血清前S1抗原,ELISA法测定乙肝病毒血清标记,荧光定量PCR检测血清乙肝病毒DNA。结果分析常规HBV血清标记物不同组合模式发现,HBeAg阳性模式中前S1抗原的检出率显著高于HBeAb阳性模式,其中S1抗原和HBeAg的符合率达80.88%;HBV-DNA阳性组前S1抗原的检出率明显高于HBV-DNA阴性组,两者的总体符合率达80.27%。结论血清前S1抗原与HBV-DNA、HBeAg相互关联,可以作为HBV存在和复制的标志。联合检测前S1抗原与HBV-DNA、HBeAg可相互补充、印证,对判断乙肝病毒的复制和存在更有价值。

Clinical significance of a hepatitis B virus serological markers-pre-S1 antigen

Objective To discuss the relationships among hepatitis B virus(HBV) Pre-S_1Ag,HBV serological markers and HBV-DNA.Methods Serum pre-s1Ag and traditional HBV serological markers were determined by enzyme-linked Immunosorbent assay(ELISA) and HBV-DNA was tested by polymerase chain reaction(PCR).Results It was discovered that the positive rate of pre-S_1Ag was higher in cases of HBeAg positive than that was in cases of HBeAb positive by analysing hepatitis B virus serological markers different models.The positive rate of pre-S_1Ag was higher in the HBV-DNA positive cases than that was in the HBV-DNA negative cases.Conclusion It exists Relationships among pre-S_1Ag,HBeAg and HBV-DNA.pre-S_1Ag can be regarded as a marker to value whether Hepatitis B virus is existing or copying,and it is a valuable supplementary for HBV-DNA and HBeAg.