| apelin对正常及低氧大鼠肠系膜小动脉的舒张作用及其机制 |
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| 引用本文： | 张玉青,申屠杨萍,马建设,邓婕,范小芳,胡良冈,龚永生. apelin对正常及低氧大鼠肠系膜小动脉的舒张作用及其机制[J]. 温州医学院学报, 2011, 41(5): 413-415 |
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| 作者姓名： | 张玉青 申屠杨萍 马建设 邓婕 范小芳 胡良冈 龚永生 |
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| 作者单位： | 温州医学院,机能实验教学中心、低氧医学研究所,浙江,温州,325035 |
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| 基金项目： | 浙江省自然科学基金资助项目，高原医学教育部重点实验室(第三军医大学)资助项目，温州市科技局科研基金资助项目 |
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| 摘 要： | 目的：探讨新的小分子活性肽apelin对正常和低氧大鼠离体肠系膜小动脉环的舒张作用及其与一氧化氮（NO）途径的关系。方法：36只大鼠随机均分为正常组与低氧组,采用离体小血管环灌流法,观察apelin对去甲肾上腺素（NE）预收缩的大鼠离体肠系膜动脉环的舒张效应;L-Nω-硝基精氨酸甲酯（L-NAME）阻断后,观察apelin对NE预收缩的两组大鼠离体肠系膜动脉环的舒张效应。结果：①apelin对正常组和低氧组肠系膜小动脉均有舒张效应（P〈0.05）。②apelin对低氧组的舒张效应大于正常组（P〈0.05）。③L-NAME阻断后,apelin的舒张效应明显减弱,但正常组和低氧组差异无统计学意义（P〉0.05）。结论：apelin对正常和低氧大鼠离体肠系膜小动脉均有舒张作用;apelin舒张肠系膜小动脉环的作用部分是通过一氧化氮途径实现的。
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| 关 键 词： | apelin 肠系膜动脉 低氧 一氧化氮 大鼠 |
Effect of apelin on diastolic function of mesenteric arteriole in normal and hypoxic rats and its mechanisms |
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| ZHANG Yuqing,SHENTU Yangping,MA Jianshe,DENG Jie,Fan Xiaofang,HU Lianggang,GONG Yongsheng. Effect of apelin on diastolic function of mesenteric arteriole in normal and hypoxic rats and its mechanisms[J]. Journal of Wenzhou Medical College, 2011, 41(5): 413-415 |
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| Authors: | ZHANG Yuqing SHENTU Yangping MA Jianshe DENG Jie Fan Xiaofang HU Lianggang GONG Yongsheng |
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| Affiliation: | ZHANG Yuqing,SHENTU Yangping,MA Jianshe,DENG Jie,Fan Xiaofang,HU Lianggang,GONG Yongsheng.Teaching Center of Medical Functional Experiment,Institute of Hypoxia Medicine,Wenzhou Medical College,Wenzhou,325035 |
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| Abstract: | Objective: To investigate the diastolic effect of apelin on mesenteric artery ring and its relationship with nitric oxide(NO) pathway in normal and hypoxic rats.Methods: Thirty-six male Sprague-Dawley rats were randomly divided into normal control group and hypoxia group.The mesenteric arteriolar diastolic activity in vitro was used.After norepinephrine(NE) pre-contraction,apelin relaxed the mesenteric artery ring in a dose-dependent manner.The relaxation effect of apelin was significantly attenuated in the... |
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| Keywords: | apelin the mesenteric artery hypoxia nitric oxide rats |
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