| 胰岛再生源蛋白与肝脏疾病和肝再生 |
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| 引用本文： | 王改平,陈萌,赵聪聪陈莎莎徐存拴.胰岛再生源蛋白与肝脏疾病和肝再生[J].解剖学报,2017,48(4):488-492. |
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| 作者姓名： | 王改平 陈萌 赵聪聪陈莎莎徐存拴 |
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| 作者单位： | 1.河南师范大学生命科学学院，河南 新乡 453007; 2.河南省 科技部共建细胞分化调控国家重点实验室培育基地，河南 新乡 453007 |
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| 摘 要： | 胰岛再生源蛋白 (Reg) 是相对分子质量为16kD的分泌型蛋白，属于C类凝集素超家族成员。Reg蛋白是1个多功能分子，主要参与调控胰腺、胃、肠和肝脏中细胞的生长和增殖，在消化性疾病及癌症的发展和预后中发挥重要作用。我们主要综述了Reg对肝脏疾病和肝再生调控的研究进展，包含其在消化性疾病中介导的信号通路，为开展Reg在相关疾病诊疗及促进肝再生中的应用研究提供重要理论基础。
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| 关 键 词： | 胰岛再生源蛋白 肝脏疾病 肝再生 |
| 收稿时间： | 2016-12-05 |
| 修稿时间： | 2017-02-07 |
Roles of regenerating islet-derived protein family in liver diseases and liver regeneration |
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| WANG Gai-ping CHEN Meng ZHAO Cong-cong CHEN Sha-sha XU Cun-shuan.Roles of regenerating islet-derived protein family in liver diseases and liver regeneration[J].Acta Anatomica Sinica,2017,48(4):488-492. |
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| Authors: | WANG Gai-ping CHEN Meng ZHAO Cong-cong CHEN Sha-sha XU Cun-shuan |
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| Institution: | 1.College of Life Science, He’nan Normal University, He’nan Xinxiang 453007, China; 2. State Key Laboratory Cultivation Base for Cell Differentiation Regulation, He’nan Normal University, He’nan Xinxiang 453007, China |
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| Abstract: | Regenerating islet-derived protein (Reg) are a group of 16 kD secretory proteins and belong to the C-type lectin superfamily. Reg proteins are multi-functional molecules, which are mainly involved in regulating cell growth and proliferation in pancreas, stomach, intestine and liver, and play an important role in the development and prognosis of digestive diseases and cancers. We reviewed research progress of the complex roles of Reg family in liver diseases and liver regeneration, including Reg family-mediated signaling pathways in digestive diseases, and laid an important theoretical foundation for application of Reg family in the diagnosis, treatment of digestive diseases and promotion of liver regeneration. |
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| Keywords: | Regenerating islet-derived protein Liver disease Liver regeneration |
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