| 唇鳞状细胞癌患者人乳头瘤病毒感染的检测分析 |
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| 引用本文： | 魏炜,张宝云,宋韫韬,孙俊勇,陈操,于文斌,徐国辉,张乃嵩,董小平,石琦.唇鳞状细胞癌患者人乳头瘤病毒感染的检测分析[J].中华实验和临床病毒学杂志,2012,26(5):356-358. |
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| 作者姓名： | 魏炜 张宝云 宋韫韬 孙俊勇 陈操 于文斌 徐国辉 张乃嵩 董小平 石琦 |
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| 作者单位： | 1. 恶性肿瘤发病机制及转化研究教育部重点实验室, 北京大学肿瘤医院暨北京市肿瘤防治研究所头颈外科,100142
2. 中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室 |
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| 基金项目： | 传染病预防控制国家重点实验室自主研究面上课题（2011SKLID211）;中国疾病预防控制中心青年科研基金资助（2012A102）;传染病预防控制国家重点实验室自主研究开放课题（2012SKLID302） |
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| 摘 要： | 目的 了解唇鳞状细胞癌患者人乳头瘤病毒感染的情况.方法 对收集到的9例临床诊断唇癌病例的石蜡组织标本应用Luminex及PCR的方法对HPV感染进行基因检测,应用免疫组织化学的方法对HPV16/18E6蛋白进行检测.结果 在9例临床诊断的唇癌病例中,通过Luminex 及PCR的方法发现1例病例具有HPV16的感染;通过免疫组织化学的方法发现7例病例具有HPV16/18的感染,总阳性率达到8/9.结论 此研究中在唇癌患者中较高的HPV感染率间接说明皮肤的直接接触对HPV感染的重要性,为阐明唇癌的发病机制提供依据.
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| 关 键 词： | 唇肿瘤 癌 鳞状细胞 乳头状瘤病毒 人 |
The analysis of human papillomavirus infection in lip squamous cell carcinoma patients |
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| WEI Wei
,
ZHANG Bao-yun
,
SONG Yun-tao
,
SUN Jun-yong
,
CHEN Cao
,
YU Wen-bin
,
XU Guo-hui
,
ZHANG Nai-song
,
DONG Xiao-ping
,
SHI Qi.The analysis of human papillomavirus infection in lip squamous cell carcinoma patients[J].Chinese Journal of Experimental and Clinical Virology,2012,26(5):356-358. |
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| Authors: | WEI Wei ZHANG Bao-yun SONG Yun-tao SUN Jun-yong CHEN Cao YU Wen-bin XU Guo-hui ZHANG Nai-song DONG Xiao-ping SHI Qi |
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| Institution: | . ＊ Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Head and Neck Surgery Department, Peking University Cancer Hospital ＆ Institute, Beijing 100142, China |
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| Abstract: | Objective To analyze the infection of human papillomavirus in lip squamous cell carcinoma patients. Methods The pathological samples of 9 clinical diagnosed lip cancer patients were collected. Lunimex and PCR techniques were used to detect the HPV gene infection and immunohistochemistry method was used to analyze the HPV protein expression in the samples. Results In the 9 eases, 1 was positive for HPV16 gene and 7 were positive for HPV16/18 E6 protein expression. The total positive rate was about 8/9. Conclusion The high HPV infection rate in lip cancer patients in the study indicated indirectly that the importance of the direct contact to the infection of HPV what was the basis for pathogenesis of the lip squamous cell carcinoma. |
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| Keywords: | Lip neoplasms Carcinoma squamous cell Papillomavirus human |
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