肺癌患者外周血中CD25^＋和CD4^＋细胞的相关性分析

目的探讨肺癌患者外周血中CD25+(IL-2R)和CD4+(Th)细胞表达水平变化的相关性.方法采用流式细胞术检测101例肺癌患者外周血中CD25+和CD4+细胞的表达水平,并对两者之间的变化关系进行了相关性分析.结果肺癌患者外周血中CD25+和CD4+细胞的检出率显著低于正常对照组(P＜0.01).对各组肺癌病例CD25+和CD4+细胞检出率的相关分析表明,两者之间呈明显的直线回归的统计相关性.结论肺癌患者外周血中CD25+细胞和CD4+细胞均明显减少,其外周血中CD25+细胞表达水平的变化可能是由CD4+细胞变化引起的.

Relativety Study between CD25+Cells and CD4+ Cells in Peripheral Blood Cells of Patients with Lung Carcinoma

Objective To study relativety between CD~ _ 25 cells and CD~ _4 cells express level in peripheral blood cells of patients with lung carcinoma.Methods CD~ _ 25 cells and CD~ _4 cells percentage were measured in peripheral blood lymphocyts from 101 patients with lung carcinoma by flow cytometry.The interrelation was analysed between CD~ _ 25 cells and CD~ _4 cells percentage among patients with lung carcinoma,patients with tumor metastase,chemothrapy patients and patients without therapy.Results CD~ _ 25 cells and CD~ _4 cells percentage of patients with lung carcinoma were lower than these of normal control (P<0.01).The relativety analysis between CD~ _ 25 cells and CD~ _4 cells percentage presented significant positive interrelation among each groups.It showed a stright line regression statistics relativety between CD~ _ 25 cells and CD~ _4 cells in peripheral blood lymphocytes of patients with lung carcinoma.Conclusion Lung carcinoma may induce significal decreasing of CD~ _ 25 and CD~ _4 cells express level in peripheral blood cells.The change of CD~ _ 25 express level may intimatly relate to CD~ _4 cells level in patients with lung carcinoma.