| 氟伐他汀对糖尿病大鼠肾组织TGF-β1表达的影响 |
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| 引用本文： | 何劲松,朱凌波,毕礼明. 氟伐他汀对糖尿病大鼠肾组织TGF-β1表达的影响[J]. 中国生化药物杂志, 2007, 28(6): 400-403 |
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| 作者姓名： | 何劲松 朱凌波 毕礼明 |
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| 作者单位： | 南京大学,医学院,附属鼓楼医院,肾脏科,江苏,南京,210008 |
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| 摘 要： | 目的探讨氟伐他汀对糖尿病大鼠肾组织TGF-β1表达的影响。方法将SD大鼠随机分为正常对照组、糖尿病组、糖尿病氟伐他汀治疗组,经氟伐他汀治疗糖尿病大鼠2,4,8周后,分别观察其对大鼠血胆固醇、血肌酐及24 h尿蛋白定量和肾组织TGF-β1表达的变化。结果与正常对照组相比糖尿病大鼠的24 h尿蛋白以及肾组织TGF-β1表达显著增加,经氟伐他汀治疗后8周,糖尿病大鼠的24 h尿蛋白明显下降,肾组织TGF-β1在蛋白和基因水平表达明显减少。结论糖尿病大鼠肾组织TGF-β1表达增加,氟伐他汀可能通过抑制糖尿病大鼠肾组织TGF-β1表达而达到延缓糖尿病肾病的进展。
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| 关 键 词： | 氟伐他汀 糖尿病 肾组织 TGF-β1 |
| 文章编号： | 1005-1678(2007)06-0400-04 |
| 修稿时间： | 2007-09-24 |
Effect of fluvastatin on expression of TGF-β1 in renal tissue of diabetic rats |
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| HE Jin-song,ZHU Ling-bo,BI Li-ming. Effect of fluvastatin on expression of TGF-β1 in renal tissue of diabetic rats[J]. Chinese Journal of Biochemical Pharmaceutics, 2007, 28(6): 400-403 |
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| Authors: | HE Jin-song ZHU Ling-bo BI Li-ming |
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| Abstract: | Purpose To investigate the effect of fluvastatin on expression of transforming growth factor-β1(TGFβ1)in renal tissue of diabetic rats.Methods Diabetes was induced by injection of streptozotocin in Sprague-Dawley rats.Diabetic rats were treated with fluvastatin for 8 weeks.Urinary protein excretion and plasma concentrations of creatinine and cholesterol were measured.The expression of TGF-β1 was detected at protein and mRNA level in renal tissue.Results Increased urinary protein excretion in diabetic rats was attenuated through treatment with fluvastatin.Overexpression of TGF-β1 was observed in renal tissue of diabetic rats and was attenuated with fluvastatin.Conclusion These findings suggest that fluvastatin may retard the progression of diabetic nephropathy by reducing expression of TGF-β1 in renal tissue. |
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| Keywords: | fluvastatin diabetes renal tissue TGF-β1 |
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