| 早孕期蜕膜组织细胞凋亡异常对妊娠的影响 |
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| 引用本文： | 丁峰,傅国强,邢福祺,陈士岭,刘以训. 早孕期蜕膜组织细胞凋亡异常对妊娠的影响[J]. 南方医科大学学报, 2002, 22(2): 145-147 |
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| 作者姓名： | 丁峰 傅国强 邢福祺 陈士岭 刘以训 |
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| 作者单位： | 1. 第一军医大学南方医院妇产科,广东广州510515
2. 中国科学院动物研究所计划生育生殖生物学国家重点实验室,北京100080 |
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| 基金项目： | WHO/洛氏基金会基金，国家计生委基金(9738)，广东省自然科学基金(970343) |
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| 摘 要： | 目的探讨早孕期蜕膜组织细胞凋亡异常与妊娠维持的关系。方法应用TUNEL法检测凋亡的发生,原位杂交和免疫组化法检测Fas、FasL的表达。结果(1)正常早孕41d蜕膜组织细胞大量凋亡,Fas、FasL的mRNA及蛋白表达较强;(2)正常早孕54d凋亡细胞明显减少,Fas、FasL的表达明显减弱;(3)早孕55d自然流产组,蜕膜组织大量凋亡,且Fas、FasL的表达较正常早孕54d显著增强(P<0.05)。结论早孕期蜕膜组织凋亡异常可能是自然流产的机制之一,Fas途径可能是诱导异常凋亡的重要因素。
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| 关 键 词： | 妊娠初期 蜕膜 凋亡 抗原 CD95 流产 自发性 |
| 文章编号： | 1000-2588(2002)02-0145-03 |
| 修稿时间： | 2001-11-14 |
Effect of abnormal apoptosis in human decidual tissue during early gestation on pregnancy |
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| DINGFeng ,FUGuo-qiang ,XINGFu-qi ,CHENShi-ling ,LIUYi-xun Departmentof ObstetricsandGynecology,NanfangHospital,FirstMilitaryMedicalUniversity,Guangzhou,China, StateKeyLaboratoryof ReproductiveBiology,Inst. Effect of abnormal apoptosis in human decidual tissue during early gestation on pregnancy[J]. Journal of Southern Medical University, 2002, 22(2): 145-147 |
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| Authors: | DINGFeng FUGuo-qiang XINGFu-qi CHENShi-ling LIUYi-xun Departmentof ObstetricsandGynecology NanfangHospital FirstMilitaryMedicalUniversity Guangzhou China StateKeyLaboratoryof ReproductiveBiology Inst |
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| Affiliation: | DINGFeng 1,FUGuo-qiang 2,XINGFu-qi 1,CHENShi-ling 1,LIUYi-xun 21 Departmentof ObstetricsandGynecology,NanfangHospital,FirstMilitaryMedicalUniversity,Guangzhou510515,China,2 StateKeyLaboratoryof ReproductiveBiology,Inst |
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| Abstract: | Objective To investigatetherelationshipbetweenabnormalcellularapoptosisof thedecidualtissueduringthe earlystagesof gestationandfailureof pregnancy.Methods Samplesof thedecidualtissuesof earlygestationwereobtained from60healthywomenwithpregnancy,andcellularapoptosiswasassessedby usingterminaltransferase-mediatednick-end labeling(TUNEL).Theexpressionsof FasandFasLinthedecidualtissuesatdifferentstagesof gestationwereexaminedby in situ hybridizationandimmunohistochemistry.Results Onday41of normalpregnancy,evidentapoptosisinthedecidual tissuesoccurredwithsignificantlyenhancedFasandFasLexpressions,whileobviousreductioninboththeapoptoticcellsand FasandFasLexpressionwasobservedon day54.Inwomenwithspontaneousabortion,increasedapoptoticcellswerepresent inthedecidualtissuesaroundday55of gestationwhensignificantlyenhancedFasandFasLmRNAandproteinexpressionsalso tookplace,incomparisonwiththoseof healthypregnantwomenon day54.Conclusion Abnormalapoptosisof thedecidua duringearlygestationmaybeoneof themechanismsforspontaneousabortion,andtheFaspathwaymayplayan importantrole inapoptosisinduction. |
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| Keywords: | pregnancytrimester first decidua apoptosis antigens CD95 abortion spontaneous |
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