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| 明胶酶B mRNA在食管癌组织中的表达 | |
| 引用本文： | 温洪涛,张岚,张蕾,李继昌.明胶酶B mRNA在食管癌组织中的表达[J].胃肠病学和肝病学杂志,2001,10(4):331-332. |
| 作者姓名： | 温洪涛 张岚 张蕾 李继昌 |
| 作者单位： | 1. 郑州大学医学院药理教研室, 2. 郑州大学第一附属医院病理科, 3. 郑州大学第一附属医院消化内科, |
| 摘 要： | 目的探讨明胶酶B mRNA在食管癌组织中表达的临床意义.方法用原位杂交法检测41例食管癌患者的癌组织及癌旁组织明胶酶B mRNA的表达.结果食管癌患者的癌组织明胶酶B mRNA的表达率(33/41)与癌旁组织的表达率(24/41)相比有显著差异(P＜0.05).有淋巴结转移食管癌患者的癌组织明胶酶B mRNA的表达率(18/19)与无淋巴结转移的表达率(15/22)相比有显著差异(P＜0.05).侵及浆膜层癌组织表达率(16/18)高于未侵及浆膜层者(17/23),但无统计学意义.结论明胶酶B在食管癌的侵袭和转移过程中可能具有重要作用. |
| 关 键 词： | 食管癌 明胶酶B mRNA 原位杂交 |
| 修稿时间： | 2001年6月16日 |
Expression of gelatinase B mRNA in human esophageal squamous cell carcinoma |
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| Wen Hongtao,Zhang Lan,Zhang Lei,et al..Expression of gelatinase B mRNA in human esophageal squamous cell carcinoma[J].Chinese Journal of Gastroenterology and Hepatology,2001,10(4):331-332. | |
| Authors: | Wen Hongtao Zhang Lan Zhang Lei |
| Institution: | Wen Hongtao,Zhang Lan,Zhang Lei,et al. Department of pharmacology,Zhengzhou University,School of medicine,Zhengzhou 450052 |
| Abstract: | Aim To investigate the expression of gelatinase B mRNA in esophageal carcinoma. Method Tumor tissues and adjacent normal tissues in 41 cases of esophageal cancer were studied by in situ hybridization. Result The rate of expression of gelatinase B mRNA in tumor tissues was significantly higher than that in adjacent tissues( P <0.05), and it was the same between esophageal cancer with and without lymph node metastasis ( P <0.05). Conclusion Gelatinase B may play an important role in tumor invasion and metastasis in esophageal carcinoma. |
| Keywords: | Esophageal carcinoma Gelatinase B mRNA in situ hybridization |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |