Critical involvement of CD40 in protection against herpes simplex virus infection in a murine model of genital herpes |
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Authors: | K. Inagaki-Ohara T. Kawabe Y. Hasegawa N. Hashimoto Y. Nishiyama |
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Affiliation: | (1) Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya, Japan, JP;(2) First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan, JP |
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Abstract: | Summary. We studied the requirement for CD40+ cells in the resolution of vaginal infection with avirulent herpes simplex virus type I (HSV-1) in vivo using CD40-deficient mice, which were susceptible to infection with avirulent HSV-1. Compared with wild-type mice, CD40-deficient mice could not eliminate HSV-1 virus effectively from the vaginal mucosa and produced lower amounts of interleukin-12 and interferon-γ. These results show that the induction and activation of CD40+ cells are important for HSV prevention, facilitating the activation of T cells to induce an efficient HSV clearance from the vaginal mucosa and to prevent lethal illness due to HSV infection. June 14, 2001 September 10, 2001 |
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