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Differential detection of nuclear envelope autoantibodies in primary biliary cirrhosis using routine and alternative methods |
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| Authors: | Elena Tsangaridou Hara Polioudaki Rania Sfakianaki Martina Samiotaki Maria Tzardi Meri Koulentaki George Panayotou Elias Kouroumalis Elias Castanas Panayiotis A Theodoropoulos |
| Institution: | (1) Department of Biochemistry, School of Medicine, University of Crete, Crete, Greece;(2) Department of Gastroenterology, School of Medicine, University of Crete, Crete, Greece;(3) Biomedical Sciences Research Center "Alexander Fleming", Vari, 16672, Greece;(4) Department of Pathology, School of Medicine, University of Crete, Crete, Greece;(5) Department of Gastroenterology, University Hospital of Heraklion, Heraklion, Crete, Greece;(6) Department of Experimental Endocrinology, School of Medicine, University of Crete, Crete, Greece |
| Abstract: | BackgroundDetection of autoantibodies giving nuclear rim pattern by immunofluorescence (anti-nuclear envelope antibodies - ANEA) in sera from patients with primary biliary cirrhosis (PBC) is a useful tool for the diagnosis and prognosis of the disease. Differences in the prevalence of ANEA in PBC sera so far reported have been attributed to the methodology used for the detection as well as to ethnic/geographical variations. Therefore, we evaluated the prevalence of ANEA in sera of Greek patients with PBC by using methods widely used by clinical laboratories and a combination of techniques and materials. |
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