卵巢癌P-糖蛋白、GST-π、P53、P185表达对近期化疗效果的影响

 目的:评价卵巢癌P-糖蛋白、P53、P185表达对近期化疗效果的影响及相互关系。方法:免疫组织化学ABC法检测49例卵巢癌P-糖蛋白、GST－π、P53、P185表达。结果:1.卵巢癌P-糖蛋白、GST－π、P53、P185表达阳性者的近期化疗有效率分别为14.3％。27.3％、41、67％、24、63％,而表达阴性者的近期化疗有效率分别为53.6％(P0.05)、75.0％(P<0.005)。2.P-糖蛋白、P185的表达存在相关性(P＜0.05)。结论:卵巢癌P-糖蛋白、GST－π、P185的表达明显影响其近期化疗效果。P-糖蛋白、P185表达的相关性值得进一步研究。

Expression of P-GP,GST-π,p53 and P185 in ovarian carcinomas and relationship with response to chemotherapy

To evaluate the response to chemotherapy and relationship on expressionfo P-GP, GST-π, P⁵³, P¹⁸⁵in ovarian carcinomas.methods: lmmunohistochemical technique ABC was used to detect P-GP,GST-π,P⁵³, P¹⁸⁵content in 49 cases of ovarian carcinomas.results: 1.The response rates to chemotherapy of patients with positive stainingof P-GP, GST-π, P⁵³, P¹⁸⁵ were 14% 、27.3%、 41.7%、 24.3% respectively: but thoserates of patients with negative staining were 53.6% (P<0.005)、 56.3% (P<0.005)、48.2% (P<0.05)、 75.0% (P<0.005) respectively.2.There was a close correlation between expression of P-GP and P¹⁸⁵ (P<0.05).conclusions: Expression of P GP,GST-π,P⁵³and P¹⁸⁵ affect the recent results of chemotherapy obviously in ovarian carcinomas.There was a researched value in depth on relationship between expression of P-GP and P¹⁸⁵.