bc1-2、P53和c-erb-B2基因在前列腺癌中的表达

 探讨癌基因在前列腺癌发生发展中意义,应用免疫组化S－P(过氧化物酶—链霉卵白素)法对50例前列腺癌组织中bcl－2、P53和c－erb－B2的表达产物进行检测。结果bcl－2、P53和c－erb－B2的表达率为42％、48％和44％,bcl－2、P53和c－erb－B2的表达与肿瘤的分级、分期皆相关。66％肿瘤有癌基因表达异常,26％的肿瘤同时有多个癌基因表达异常,多个癌基因表达异常与分级、分期相关,bcl－2的表达与P53的表达呈负相关:(γ＝-0.51,P<0.05)。结论:上述癌基因参与了前列腺癌发生发展过程,肿瘤多个基因分析比单个分析更有价值。

Expression of bcl-2,p53 and c-erb-B2 in Prostate Cancer

To find the significance of oncogenes in the development of prostate cancer.Meth-ods: The expression of bcl-2,P⁵³and c-erb-B₂ in prostate cancer tissue of 50 cases wereobserved by immunohistochemical SP method.Results: (1) The expression of bcl-2,P⁵³and c-erb-B₂, was 42% 48% and 44% respectively.Expression of bcl-2,P⁵³and c-erb-B₂were closely related to the tumor grade and clinical stage; bcl-2 inversly related to P⁵³(r=-0.51, P<0.05).(2) Expression of one or more oncogenes were 66% and 26% inmultiple oncogenes.Expression of multiple oncogeres were closely related to the tumorgrade and clinical stage.Conclusions: These results showed that: (1) bcl-2, P⁵³and cerb-B₂ are involved in tumorgenesis and development of prostate cancer.(2)The detection of multiple oncogenes is more valuable than that of single one.