甲状腺素治疗对妊娠合并甲减患者妊娠结局及子代的影响研究

目的探讨甲状腺素治疗对妊娠合并甲减患者妊娠结局及子代的影响价值。方法选取264例妊娠合并甲减患者纳入本次研究工作,分为两组。两组均监测甲状腺功能,研究组采用甲状腺素治疗,对照组接受常规补碘治疗。比较两组的妊娠结局及子代影响。结果两组胎膜早破率及剖宫产率比较,差异无统计学意义(P0.05);研究组的流产率、早产率均明显低于对照组(P0.05);两组胎儿畸形率比较,差异无统计学意义(P0.05),研究组胎儿窘迫率及胎儿生长受限率均低于对照组(P0.05)。结论妊娠合并甲减患者应用甲状腺素治疗可以改善妊娠结局,降低子代影响。

Influence of thyroxin on pregnancy outcome and offspring in pregnant patients with hypothyroidism

Objective To investigate the influence value of thyroxin on pregnancy outcome and offspring in pregnantpatients with hypothyroidism. Methods 264 pregnant patients with hypothyroidism were included and divided into two groups. Thyroid function in two groups was monitored. Patients in study group were treated with thyroxin while patients in control group were treated with conventional treatment of iodine. Influence on pregnancy outcome and offspring were compared and analyzed. Results The incidence of premature rupture of fetal membranes and the prevalence of cesarean section in two groups were not different (P>0.05)/ The incidence of abortion and the incidence of premature delivery in study group were significantly lower than those in control group (P<0.05). The incidence of fetal anomaly in two groups was not different (P>0.05). The incidence of fetal distress and the rate of fetal growth restriction in study group were lower than those in control group (P<0.05). Conclusion Treatment of thyroxin could improve the pregnancy outcomeand reduce the influence on offspring in pregnant patients with hypothyroidism.