红景天对OSAHS相关的PAH患者心功能的辅助治疗作用

目的观察红景天胶囊治疗后,阻塞性睡眠呼吸暂停综合征(Obstructive sleep apnea syndrome,OSAHS)相关的肺动脉高压(Pulmonary hypertension,PAH)患者心功能及睡眠相关指标等方面的改变。方法选择2016年7月~2017年4月60例我院住院患者,经多导睡眠图(PSG)或睡眠初筛检查及心脏彩超检查确诊为OSAHS合并有PAH,随机分为治疗组及对照组各30例。对照组患者给予OSAHS相关治疗,治疗组在对照组的基础上给予红景天胶囊口服,治疗时间为4周。4周后观察患者肥胖指数(Body mass index,BMI)、睡眠监测的呼吸暂停低通气指数(Apnea hypopned index,AHI)及脑钠肽(Brain natriuretic peptide,BNP)指标改变情况。结果治疗后治疗组BNP为(246.9±98.6)pg/m L,对照组为(679.8±108.8)pg/m L,差异有统计学意义(P0.05)。而治疗后,两组患者的BMI值分别为(28.3±8.0)kg/m~2和(28.8±9.8)kg/m~2,AHI分别为(27.0±7.6)次/h和(25.7±7.2)次/h,差异无统计学意义(P0.05)。结论红景天胶囊可以通过改善血流变指标,改善心脏对缺氧的耐受性,使心功能好转。

The adjuvant therapeutic effect of Rhodiola rosea on cardiac function in OSAHS related PAH patients

Objective To observe the changes of cardiac function and sleep-related indexes in patients with obstructivesleep apnea syndrome (OSAHS) related pulmonary hypertension (PAH) after treatment with Rhodiola capsules. Methods 60 hospitalized patients diagnosed as OSAHS complicated with PAH by polysomnography (PSG) or sleep screening test and echocardiography in our hospital from July 2016 to April 2017 were selected. The patients were randomly divided into observation group and treatment group with 30 cases in each group. Patients in the control group were given OSAHS-related treatment. The observation group was given Rhodiola capsules orally on the basis of the control group.Treatment duration lasted for 4 weeks. The changes of body mass index (BMI), sleep apnea hypopnea index (AHI) and brain natriuretic peptide (BNP) index were observed after 4 weeks. Results After treatment, BNP was (246.9±98.6) pg/mL in the observation group and(679.8±108.8) pg/mL in the control group. The differences between the two groups were significant (P<0.05). After treatment, BMI for the two groups were (28.3±8.0) kg/m2 and(28.8±9.8) kg/m2, respectively; AHI were(27.0±7.6) times/h and(25.7±7.2) times/h, respectively. There was no statistical significance of the difference of the two indicators between two groups(P>0.05). Conclusion Rhodiola capsules can improve cardiac function by improving the indexes of blood rheology and the tolerance of heart to hypoxia.