木香生品与麸煨品的药效研究

目的:研究木香生品和麸煨品不同极性部位的药理作用.方法:SPF级雄性SD大鼠,随机分为10组.大鼠禁食(不禁水)24h后,各组口服给予生理盐水、木香生品水煎液(2,6 g·kg-1)、麦麸制木香水煎液(2,6 g·kg-1)、木香生品挥发油(2,6 g·kg-1)、麦麸制木香挥发油(2,6 g·kg-1),1h后采用盐酸-乙醇所致大鼠胃黏膜急性损伤模型,考察木香及其麸制品对胃肠功能的影响.结果:木香生品及其麸制品的挥发油(2,6 g·kg-1)均可显著降低盐酸-乙醇所致大鼠胃黏膜溃疡指数(P＜0.01),而且木香麸煨品的高剂量挥发油对大鼠胃黏膜损伤保护作用强于生品(P＜0.05).木香麸制前后(2,6 g·kg-1)对盐酸-乙醇所致胃黏膜损伤大鼠的胃泌素分泌量影响较小,只有木香生品(2 9·kg“)有增加胃泌素含量作用(P＜0.01).结论:木香麸煨后对大鼠胃黏膜损伤的保护作用增强.

Pharmacologic Action of Aucklandia lappa and Processed Products

Objective:To study the pharmacology effect of different polar extracts from Aucklandia lappa and its processed products.Method:The stomach mucous membrane injury model induced by hydrochloric acid-alcohol was adopted.SD rats were divided randomly into control group,model group,A.lappa group(2,6 g·kg-1),processed products of A.lappa group(2,6 g·kg-1),volatile oil group from A.lappa(2,6 g·kg-1),volatile oil of processed products from A.lappa group(2,6 g·kg-1),the gastric percentage was calculated.Result: The essential oil of processed products from A.lappa and A.lappa(2,6 g·kg-1)significantly inhibited the injuries of gastrointestinal mucous membrane(P<0.01),and the activity of essential oil of processed products of A.lappa(6 g·kg-1) was stronger than A.lappa(6 g·kg-1).However,the influence of A.lappa on rats’ gastrin was not remarkable,only essential oil of A.lappa(2g·kg-1) exhibited enhance of rats’ gastrin. Conclusion:The essential oil of A.lappa may hence the inhibition effect on injuriy of stomach mucous membrane.