丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用

目的:考察不同质量分数的丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用.方法:用改良Franz扩散池法,以氮酮为阳性对照,不含促渗剂的磷酸川芎嗪贴剂为阴性对照,考察含3％,5％,7％,10％的丁香挥发油对模型药磷酸川芎嗪经小鼠皮肤的促渗效果,采用HPLC测定磷酸川芎嗪的含量.结果:4种质量分数的丁香油对磷酸川芎嗪12h平均累积渗透量(Q12)分别为3.030,4.066,1.845,1.205 mg·cm-2;其12h时增渗倍数分别为1.54,2.06,0.96,0.62.与阴性对照组的Q12比较,5％丁香油与3％丁香油促渗作用显著.结论:3％,5％的丁香油能明显提高磷酸川芎嗪在贴剂中的渗透量,且促渗效果好.

Percutaneous Enhancement Function of Volatile Oil from Eugenia caryophyllata on Ligustrazine Phospate Patch

Objective: To investigate percutaneous penetration effect of different concentration of volatile oil from Eugenia caryophyllata on ligustrazine phosphate (LP). Method: Modified Franz diffusion cell method was used,with azone as positive control,LP without penetration enhancers as negative control,penetration effect of 3%, 5%, 7% and 10% volatile oil from E. caryophyllata on LP through mouse skin were investigated,the content of LP was determined by HPLC. Result: Average cumulative permeation volume(Q₁₂)of the 4 concentrations of volatile oil from E. caryophyllata on LP in 12 h were 3.030, 4.066, 1.845 and 1.205 mg·cm^-2,respectively;and enhancing rates (ER) in 12 h were 1.54,2.06,0.96 and 0.62,respectively.Compared with Q₁₂ of negative control group,5% and 3% volatile oil from E. caryophyllata had significantly enhancing effect. Conclusion: 3% and 5% volatile oil from E. caryophyllata could enhance permeation volume of LP through mouse skin obviously, and had great enhancing effect.