| 正交设计试验法优选痤疮乳剂的基质及工艺 |
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| 引用本文： | 尚茂林,张士勇,王迪生.正交设计试验法优选痤疮乳剂的基质及工艺[J].中国药房,2005,16(10):739-740. |
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| 作者姓名： | 尚茂林 张士勇 王迪生 |
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| 作者单位： | 1. 安徽蚌埠医学院附属第二医院药剂科,蚌埠市,233040
2. 安徽蚌埠市第三人民医院药剂科,蚌埠市,233000 |
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| 摘 要： | 目的:优选痤疮乳剂的基质及工艺。方法:用正交设计法,以油相、乳化剂和乳化温度为可变因素,选用L9(34)进行试验。结果:最优的基质组成及工艺为硬脂酸15g,液体石蜡13g,凡士林20g,三乙醇胺3g,乳化温度85℃。结论:该法制备的乳剂符合《中国药典》的规定
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| 关 键 词： | 正交设计法 痤疮乳剂 基质 工艺 |
| 文章编号： | 1001-0408(2005)10-0739-02 |
| 修稿时间： | 2004年8月12日 |
Optimization of Matrix Composition and Technique for Acne Emulsion by Orthogonal Design Method |
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| SHANG Maolin,WANG Disheng,Zhang Shiyong.Optimization of Matrix Composition and Technique for Acne Emulsion by Orthogonal Design Method[J].China Pharmacy,2005,16(10):739-740. |
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| Authors: | SHANG Maolin WANG Disheng Zhang Shiyong |
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| Abstract: | OBJECTIVE:To optimize matrix composition and technique for acne emulsion.METHDOS:Oil phase,emulsifier and emulsify temperature were selected as variable factors using orthogonal design method,and table L 9 (3 4 )was used for the experiment.RESULTS:The optimum matrix composition and technique were stearic acid of15g,liquid paraffin of13g,vaseline of20g,trietha nolamine of3g,emulsifying temperature of85℃.CONCLUSIONS:The acne emulsion prepared by this kind of composition and technique accord with the stipulation of Chinese Pharmacopoeia. |
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| Keywords: | Orthogonal design method Acne emulsion Matrix composition Technique |
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