实热证、虚热证造模大鼠甲状腺超微结构及功能对比研究

观察实热证、虚热证大鼠血清三碘甲状腺原氨酸（T3）、四碘甲状腺原氨酸（T4）、反三碘甲状腺原氨酸（rT3）和促甲状腺激素（TSH）浓度及甲状腺结构改变。用中药灌服大鼠，形成实热证、虚热证模型，运用放射免疫测定和电镜技术观察。结果，虚热造模组血清T3、T4水平显著升高，rT3水平呈下降趋势；虚热造模组甲状腺滤泡上皮比实热造模组改变明显。表明甲状腺激素和甲状腺超微结构改变可作为热造模组改变明显。表明甲状腺激素和甲状腺超微结构改变可作为热证虚实比较的重要依据。

Comparative Study on Ultramicrostructures and Functions of the Thyroid in Rats of Excess-Heat Type and Deficiency-Heat Type

Serum contents of triiodothyronine (T3), tetraiodothyronine (T4), reverse triiodothyronine (rT3) and thyroid - stimulating hormone (TSH) and changes of structures of the thyroid gland in the rat of exces - heat syndrome and deficiency - heat syndrome were observed with radioimmunoassay and electron microscopic technique, respectively. The rats of excess - heat syndrome and deficiency - heat syndrome were established with administration of Chinese herbs. Results indicated that serum T3 and T4 levels increased and the rT3 level tended to decrease in the deficiency - heat group, and thyroid follicle epithelial cell had more significant changes as compared with that of the excess - heat group. It is suggested that changes of hormones and ultra - microstructures of the thyroid can be served as an important basis for heat syndrome of deficincy type and excess type.