Axonal regeneration in dorsal spinal roots is accelerated by peripheral axonal transection |
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| Authors: | P.M. Richardson V.M.K. Verge |
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| Affiliation: | 1. Department of General Practice, Erasmus MC, Rotterdam, The Netherlands;2. FS Fysio, Capelle aan den IJssel, The Netherlands;3. Faculty of Human Movement Sciences, VU, Amsterdam, The Netherlands;4. Fysiotherapie Kapellaan/Ouwerkerk, Vught, The Netherlands;5. Department of Epidemiology and Biostatistics, VU University Amsterdam and the EMGO Institute for Health and Care Research, Amsterdam, The Netherlands;6. Department of Health Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands;1. Faculty of Traditional Medicine, Hanoi Medical University, Hanoi, Vietnam;2. Department of Medical Statistics and Informatics, Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam;3. National Hospital of Traditional Medicine, Hanoi, Vietnam;4. Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam |
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| Abstract: | Regeneration of crushed axons in rat dorsal spinal roots was measured to investigate the transganglionic influence of an additional peripheral axonal injury. The right sciatic nerve was cut at the hip and the left sciatic nerve was left intact. One week later, both fifth lumbar dorsal roots were crushed and subsequently, regeneration in the two roots was assessed with one of two anatomical techniques. By anterograde tracing with horseradish peroxidase, the maximal rate of axonal regrowth towards the spinal cord was estimated to be 1.0 mm/day on the left and 3.1 mm/day on the right. Eighteen days after crush injury, new, thinly myelinated fibers in the root between crush site and spinal cord were 5-10 times more abundant ipsilateral to the sciatic nerve transection. The central axons of primary sensory neurons regenerate more quickly if the corresponding peripheral axons are also injured. |
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| Keywords: | Axonal regeneration Spinal root Sensory neuron Transganglionic Enhancement |
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