| 生脉散提取物对实验性病毒性心肌炎的作用 |
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| 引用本文： | 王秋娟,雷智刚,严永清,朱丹妮,余伯阳.生脉散提取物对实验性病毒性心肌炎的作用[J].中国天然药物,2004,2(5):313-318. |
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| 作者姓名： | 王秋娟 雷智刚 严永清 朱丹妮 余伯阳 |
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| 作者单位： | 1. 中国药科大学生理教研室,南京,210009
2. 中国药科大学中药复方研究室,南京,210038 |
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| 基金项目： | “九五”国家科技攻关项目 (No 96 90 3 0 1 0 7)，国家“863计划”创新药物基金，中药现代化专项基金 (No 2 0 0 2AA2 2 3 2 0 9)~~ |
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| 摘 要： | 目的：观察生脉散提取物(SMT)对实验性病毒性心肌炎的治疗作用。方法：BAIB／c小鼠腹腔注射CVB3后，第4天出现病毒性心肌炎体征，到第8天病变到达高峰，形成病毒性心肌炎动物模型。通过观察小鼠体重变化，血清中LDH、AST和MDA的含量，心肌组织中病毒滴度，心肌组织病理变化和超微结构变化，研究SMT对实验性病毒性心肌炎的治疗作用。结果：SMT提高心肌炎小鼠的体重增长速度；降低血清中LDH、AST及MDA的含量；改善心脏病理变化，改善心肌组织的超微结构；抑制病毒在心肌组织内的增殖。结论：SMT对病毒性心肌炎有一定的治疗作用，其作用机理与抗氧化和抑制病毒在心肌组织中复制有关。
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| 关 键 词： | 病毒性心肌炎 心肌组织 性病 实验性 治疗作用 生脉散 小鼠 |
| 文章编号： | 1672-3651(2004)05-0313-06 |
| 修稿时间： | 2003年12月16 |
Effect of SMT on Experimental Viral Myocarditis |
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| WANG Qiu Juan ,LEI Zhi Gang ,YAN Yong Qing ,ZHU Dan Ni ,YU Bo Yang.Effect of SMT on Experimental Viral Myocarditis[J].Chinese JOurnal of Natural Medicines,2004,2(5):313-318. |
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| Authors: | WANG Qiu Juan LEI Zhi Gang YAN Yong Qing ZHU Dan Ni YU Bo Yang |
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| Abstract: | AIM: A model of viral myocarditis was established to study the effect of SMT(A Chinese patient drug) on myocarditis with CVB 3 infected mice METHOD: CVB 3 infected BALB/c mice show myocarditis physical charicteristics at day 4,and myocardial pathological changes reach topmost at day 8,and through this way a model of viral myocarditis was established successfully Through the change of mice weight,the contents of AST,LDH,SOD and MDA in sera,virus titer in myocytes,the change of myocardial pathology and ultrastructure,we studied the effect of SMT on myocarditis of mice infected with CVB 3 RESULT:SMT could promote the growth of mice weight;reduce the content of AST,LDH and MDA in sera;improve myocardial pathological changes and myocardial ultrastructure;repress virus replication in myocytes CONCLUSION: SMT had therapeutical effect on murine myocarditis,and the mechanism of this effect was associated with the effect of antioxidation and repressing virus replication in myocytes |
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| Keywords: | Sheng Mai San Viral myocarditis CVB 3 |
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