Potential modelling of acrylic acid copolymer nanoparticles by small angle X-ray scattering |
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| Affiliation: | 1. Department of Pharmaceutics, E.-M.-Arndt-University, Jahnstr. 17, 17489 Greifswald, Germany;2. Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany;1. Post-graduate Program in Food Engineering and Science, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, Rio Grande, Rio Grande do Sul State 96201-900, Brazil;2. Departamento de Tecnologia, Universidade Estadual de Maringá, Av. Dr. Ângelo Moreira da Fonseca, 1800 Umuarama, Paraná State 87506-370, Brazil;1. School of Government Management, Shanghai University of Political Science and Law, Shanghai, 201701, China;2. School of Economics and Management, Tongji University, Shanghai, 200092, China;1. Department of Molecular and Biomolecular Physics, National Institute of R&D of Isotopic and Molecular Technologies, Donat 67-103, Cluj-Napoca 400293, Romania;2. Faculty of Physics, Babeș-Bolyai University, Kogălniceanu 1, Cluj-Napoca 400084, Romania;3. Chair for Analytical Chemistry, Institute of Hydrochemistry, Technische Universität München, Marchioninistrasse 17, Munich 81377, Germany |
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| Abstract: | Copolymer nanoparticles of acrylic acid, acrylic amide, acrylic butyl acrylate and methyl acrylate were characterised using a parameter relevant for in vivo organ distribution: charge distribution. Usually the zeta potential is estimated with laser Doppler anemometry as an equivalent for the particle charge. In our case, the potential distribution was investigated by small angle X-ray scattering. The nanoparticles shielded by counter-ions at high ionic strength (0.15 M NaCl solution) have short-range potentials. Different potential models were calculated: Percus–Yevick potential and Hypernetted Chain potential. The potentials estimated by small angle X-ray scattering can be divided into attractive and repulsive parts. The attractive potential, indicated by a minimum, is not significant compared with the repulsive potential and can be ignored. Consequently the tendency to form Van der Waals clusters is low. The solution shows a random order of hard spheres. Therefore, surface charges on the nanoparticles should hamper such carrier cell interaction only at short distances. In comparison with the potential estimation by laser Doppler anemometry (32.8 mV), results of the same order of magnitude were obtained using the small angle X-ray scattering method. The advantage of this method is that it provides a potential curve, which allows better appraisal of clearance by the reticuloendothelial system. By interpreting the potential curves, a more detailed prediction of steric stability of particle systems is possible. |
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