Tumor induction in F344/N rats and B6C3F1 mice following inhalation exposure to ethylbenzene |
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| Affiliation: | 1. National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA;2. IIT Research Institute, Chicago, IL 60616, USA;1. Inserm UMR 1033, université de Lyon, 69437 Lyon, France;2. Service de rhumatologie et de pathologie osseuse, hôpital E.-Herriot, 5, place d’Arsonval, 69437 Lyon, France;1. Biofrontera Bioscience GmbH, Hemmelrather Weg 201, 51377 Leverkusen, Germany;2. Institute of Animal Physiology, Ruhr-University Bochum, 44780 Bochum, Germany;1. Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India;2. National Institute of Pharmaceutical Education and Research, Hyderabad 500037 India;3. Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India;4. Institut des Sciences Chimiques de Rennes, CNRS UMR 6226, Avenue du Général Leclerc, 35042 Rennes Cedex, France;1. Cultex Laboratories GmbH, Feodor-Lynen-Str. 21, 30625 Hannover, Germany;2. Karlsruhe Institute of Technology, Institute of Economics, Econometrics and Statistics, Blücherstr. 17, 76185 Karlsruhe, Germany;3. Vor der Hardt 16, 57392 Oberkirchen, Germany |
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| Abstract: | Carcinogenesis studies of ethylbenzene were conducted because of its extensive use as a solvent and because it is structurally similar to the known carcinogen benzene. Groups of 50 male and 50 female Fischer rats and B6C3F1 mice were exposed to ethylbenzene by inhalation at 0, 75, 250, and 750 ppm 6 h per day, 5 days per week, for 2 years. The dose levels were selected based on the results of 13-week studies. In the 750 ppm group of male and female rats, body weights were slightly lower and incidences of renal hyperplasia and tubular neoplasms were significantly increased compared with controls. Incidence of testicular tumors was also significantly increased in male rats. Survival and body weights of the exposed groups of male and female mice and controls were comparable. Incidences of alveolar epithelium metaplasia, alveolar/bronchiolar adenoma, and hepatocyte hypertrophy and necrosis were significantly increased in the 750 ppm male mice and incidences of liver eosinophilic foci and hepatocellular neoplasms were significantly increased in the 750 ppm female mice compared with controls. Ethylbenzene is carcinogenic inducing neoplasms in kidneys and testes in Fischer rats and in lungs in male and liver in female B6C3F1 mice. |
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