Effects of ginseng total saponin on morphine-induced hyperactivity and conditioned place preference in mice |
| |
| Affiliation: | 1. College of Pharmacy, Chungbuk National University, Cheongju 361-763, South Korea;2. University of Mississippi Medical Center, Jackson, MS 39216-4045, USA;3. National Institute of Toxicological Research, Seoul 122-040, South Korea;4. College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, South Korea;5. Korea Research Institute of Chemical Technology, Taejon 305-606, South Korea;1. Laboratório de Retroviroses, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;2. Setor de Medicina Veterinária Preventiva, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil;3. Hospital Veterinário, Instituto de Medicina Veterinária, Universidade Federal do Pará, Castanhal, Pará, Brazil;4. Ministério da Agricultura Pecuária e Abastecimento—LANAGRO, Pedro Leopoldo, Minas Gerais, Brazil;1. Department of Health Policy and Administration, Washington State University, Spokane, Washington;2. Program of Excellence in Addictions Research, Washington State University, Spokane, Washington;1. Cancer Biology and Inflammatory Disorder Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, India;2. Department of Pathology, Institute of Postgraduate Medical Education and Research and Institute of Post-Graduate Medical Education and Research Hospital, Kolkata, India;3. German Cancer Research Center Heidelberg, D0104 Tumor Immunology Programme, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany |
| |
| Abstract: | A single or repeated administration of morphine in mice produced hyperactivity, conditioned place preference (CPP) and postsynaptic dopamine (DA) receptor supersensitivity. The hyperactivity induced by morphine was evidenced by measuring the enhanced ambulatory activity using a tilting-type ambulometer. CPP effects were evaluated assessing the increased time spent by the mice to morphine and the inhibition of CPP by the decreased time spent by the mice in the white compartment. Postsynaptic DA receptor supersensitivity in mice displaying a morphine-induced CPP was evidenced by the enhanced response in ambulatory activity to the DA agonist, apomorphine (2 mg/kg, s.c.). The intraperitoneal injection of ginseng total saponin (GTS) from the root of Panax ginseng C.A. Meyer (Araliaceae), prior to and during the morphine treatment in mice inhibited morphine-induced hyperactivity and CPP. GTS inhibited the development of postsynaptic DA receptor supersensitivity. A single dose administration of GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic action of GTS at the postsynaptic DA receptor. These results suggest that the development of morphine-induced CPP may be associated with the enhanced DA receptor sensitivity and that GTS inhibition of the morphine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by morphine. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
