Reversal of cisplatin-induced delay in gastric emptying in rats by ginger (Zingiber officinale) |
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| Institution: | 1. School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China;2. Department of Obstetrics and Gynecology, First People’s Hospital of Yunnan Province, Kunming 650032, PR China;3. Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, PR China;4. Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, PR China;5. Department of Pharmacology, Yunnan University of Traditional Chinese Medicine, Kunming 650050, PR China;1. Institute for Cellular & Molecular Biology, The University of Texas at Austin, Molecular Biology Building, 2500 Speedway Stop A4800, Austin, TX 78712, USA;2. McKetta Department of Chemical Engineering, Cockrell School of Engineering, The University of Texas at Austin, 200 E. Dean Keeton St. Stop C0400, Austin, TX 78712, USA;2. Department of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark;3. Aarhus University, Århus, Denmark;4. Department of General Psychiatry, Mental health services in Region of Southern Denmark;1. AP-HP, Department of Radiation Oncology, University of Paris-Est, Créteil, France;2. AP-HP, Henri Mondor Breast Center, University of Paris-Est, Créteil, France;3. INSERM, UMR1052, Radiobiology Group, Cancer Research Centre of Lyon, Lyon, France;1. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China;2. State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China;3. Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, 650118 Kunming, China |
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| Abstract: | Cisplatin causes nausea, vomiting and inhibition of gastric emptying. We have demonstrated the antiemetic effect of the acetone and ethanolic extract of ginger (Zingiber officinale, Roscoe, Zingiberacae) against cisplatin-induced emesis in dogs. In the present study, the acetone and 50% ethanolic extract of ginger in the doses of 100, 200 and 500 mg/kg (p.o.) and ginger juice, in the doses of 2 and 4 ml/kg, were investigated against cisplatin effect on gastric emptying in rats. All three ginger preparations significantly reversed cisplatin-induced delay in gastric emptying. The ginger juice and acetone extract were more effective than the 50% ethanolic extract. The reversal produced by the ginger acetone extract was similar to that caused by the 5-HT3 receptor antagonist ondansetron; however, ginger juice produced better reversal than ondansetron. Therefore, ginger, an antiemetic for cancer chemotherapy, may also be useful in improving the gastrointestinal side effects of cancer chemotherapy. |
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