Screening of Australian medicinal plants for antiviral activity |
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| Affiliation: | 1. Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt;2. Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany;3. Medical Laboratories Technology Department, Faculty of Applied Medical Sciences, Taibah University, Al- Madinah Al-Munwarah, Saudi Arabia;1. School of Health, Medical and Applied Sciences, Central Queensland University, Bruce Hwy, North Rockhampton, Queensland 4701, Australia;2. Institute of Future Farming Systems, Central Queensland University, Bruce Hwy, North Rockhampton, Queensland 4701, Australia;1. The University of Queensland, Queensland Alliance for Agriculture and Food Innovation, Coopers Plains, Queensland, Australia;2. Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia;3. School of Environment and Science, Griffith University, Nathan, Queensland, Australia;4. The University of Queensland, Centre for Advanced Imaging, Brisbane, Queensland, Australia;5. Chair of Analytical Food Chemistry, Technical University of Munich, Maximus-von-Imhof-Forum 2, D-85354, Freising, Germany;6. The Arnhem Land Progress Aboriginal Corporation, Yirrkala, Northern Territory, Australia;7. Queensland Health Forensic and Scientific Services, Brisbane, Queensland, Australia |
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| Abstract: | Extracts of 40 different plant species used in the traditional medicine of the Australian Aboriginal people have been investigated for antiviral activity. The extracts have been tested for activity against one DNA virus, human cytomegalovirus (HCMV) and two RNA viruses, Ross River virus (RRV) and poliovirus type 1, at non-cytotoxic concentrations. The most active extracts were the aerial parts of Pterocaulon sphacelatum (Asteraceae) and roots of Dianella longifolia var. grandis (Liliaceae), which inhibited poliovirus at concentrations of 52 and 250 μg/ml, respectively. The extracts of Euphorbia australis (Euphorbiaceae) and Scaevola spinescens (Goodeniaceae) were the most active against HCMV. Extracts of Eremophila latrobei subsp. glabra (Myoporaceae) and Pittosporum phylliraeoides var. microcarpa (Pittosporaceae) exhibited antiviral activity against RRV. |
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