定心胶囊对房颤大鼠P-选择素影响的实验研究

目的：探讨定心胶囊对房颤大鼠P-选择素的作用机制，研究开发中药治疗房颤及预防房颤后血栓。方法：采用氯化钙-乙酰胆碱混合液以鼠尾静脉给药的方式建立房颤的动物模型。筛选具有典型房颤心电图表现的大鼠30只，随机分为房颤模型组、定心胶囊治疗组、雏拉帕米对照组和正常对照组，共4组。定心胶囊治疗组、维拉帕米对照组给药治疗，4周后，测定血清中P-选择素的含量。结果：①治疗组（包括西药、定心胶囊组）与模型组比较，治疗组血清中P-选择素含量明显降低，P〈0．01，说明有显著意义，治疗有效。②定心胶囊组与西药对照组比较，P〉0．05，没有统计学意义，说明定心肢囊与西药雏拉帕米对房颤的治疗与预防作用是相近的。结论：定心胶囊能够降低血清中P-选择素的含量，减低血小板活化，对房颤大鼠血栓形成和血栓栓塞有预防和治疗作用。

The Experimental Study on the Effective Therapy of P-selection for Dingxin Capsule to the Rats of Atrial Fibrillation(AF)

Objective:The aim of this study is to develop the effective therapy for atrial fibrillation(AF),and study the mechanisms of Dingxin capsule.To elucidate the role of platelet P-selection in the pathogenesis of AF.Methods: 36 rats were randomized to 4 groups: normal control group,model group,Dingxin capsule curatio group,Verpamil intervention group.Plasma P-selection was measured with ELISA.Results:With the comparisonof treating group and model group,the level of P-selection in treating group lowed obviously(P<0.01).It had statistic significance.The express level of platelet P-selection of Dingxin capsule curatio group and the Verpamil intervention group have similar effect to AF(P>0.05).It had not statistic significance.Conclusion:The research results showed that Dingxin capsule could low the expression of P-selection,which played important function in the treatment of AF.