口腔扁平苔癣固有层TNF-α、TGF-β的表达及其临床意义

目的：观察肿瘤坏死因子-α（TNF-α）和转化生长因子-β（TGF-β1、TGF-β2）在口腔扁平苔癣（OLP）固有层中的表达特征及其意义。 方法： 用免疫组织化学方法检测TNF-α、TGF-β1，TGF-β2在OLP和正常口腔粘膜（NOM）组织中的细胞定位和表达量。 结果： OLP固有层中TNF-α阳性率77.27%(17/22), 表达权重与对照组相比P<0.01。阳性信号主要位于巨噬细胞、淋巴细胞等胞浆内或胞膜上。TGF-β1阳性率45.45%, 表达权重与对照组相比P<0.05, 主要分布于巨噬细胞、内皮细胞和成纤维细胞内。TGF-β2阳性率27.27(6/22), 表达权重与对照组相比P>0.05，可见于细胞外间质、成纤维细胞等。 结论： OLP固有层中，TNF-α和TGF-β1的表达及其细胞定位对局部炎症的发展和维持起着重要作用。

Expression of TNF - α and TGF - β in oral lichen planus patients

AIM: To investigate the expression of TNF-α， TGF-β in patients with oral lichen planus (OLP) and normal oral mucosa (NOM). METHODS: An immunohistochemical technique was performed to detect TNF-α, TGF-β1 and TGF-β2 expression in 22 cases with OLP and 10 normal controls. RESULTS: In lamina propria of OLP, the expression of TNF-α and TGF-β1 were increased, whereas TGF-β2 did changed significantly compared with control group. TNF-α positive signal were mostly found in macrophages, lymphocytes. TGF-β1 positive cell was present in macrophages, endothelial cells and fibrocytes. CONCLUSION: TNF-α and TGF-β1 play an important role in the development and maintenance of OLP local inflammation.