内分泌失调性骨质疏松症综合治疗的临床体会

目的:探讨内分泌失调性骨质疏松症综合治疗效果。方法:对120例绝经后骨质疏松症以骨痛为主诉的患者进行综合治疗,观察症状和骨密度(BMD)改善情况。结果:116例治疗达到1a,其中104例纯药物综合治疗,12例因脊柱病理性骨折转骨科微创治疗,术后继续药物综合治疗。用药3个月后BMD与用药前比较无差异(P>0.05),用药6个月和12个月BMD与用药前比较差异有显著性(P<0.01),用药3个月患者的自觉症状(骨痛)改善明显(总疗效83%),而BMD改变的总疗效不满意(分别为64%、55%、70%)。6个月后BMD才出现较为满意的总疗效(约80%),12个月后达到十分满意的疗效(97%以上)。结论:内分泌失调性骨质疏松症首选激素替代治疗。治疗骨质疏松症是一个系统而长期的过程,远期疗效较满意。

Clinical Comprehend of Combined Therapy to Osteoporosis Caused by Endocrine Disrurbance

Objective To investigate the combined therapeutic efficacy of osteoporosis caused by endocrine disturbance. Methods 120 cases of osteoporosis after menopause whose chief complaint was osteodynia were treated by combined therapy, the improvement of symptom and bone mineral density (BMD) were observed. Results 116 cases were treated for one year. 104 cases were treated by medicine combined therapy, 12 cases were displaced to orthopedics to be mini-insult treated and treated by medicine post operation. There were no difference for BMD treating with medicine compared ahead and after 3 months (P>0.05). There were significant difference for BMD treating with medicine compared ahead and 6 or 12 months(P<0.01).The subjective symptom(osteodynia) after treating with medicine for 3 months was improved obviously(overall curative effect was 83%), The overall curative effect of BMD improments were unpreparedness(64%,55% and 70% respectively).The compared satisfying overall curative effect(about 80%) were appeard after 6 months.The well-contentcurative effect (above 97%)was showed up after 12 months. Conclusion The hormone replacement therapy is the first method to osteoporosis caused by endocrine disrurbance.Treating osteoporosis is a genealogy and long-term process,the therapeutic effect is fairly satisfaction.