| 肾上腺髓质素前体N端20肽在不同高血压病中的水平变化 |
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| 引用本文： | 张昭馥,石湘芸,费宇行,唐朝枢. 肾上腺髓质素前体N端20肽在不同高血压病中的水平变化[J]. 海军总医院学报, 2001, 14(4): 208-210 |
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| 作者姓名： | 张昭馥 石湘芸 费宇行 唐朝枢 |
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| 作者单位： | 1. 海军总医院,干三科
2. 北京医科大学 |
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| 摘 要： | 目的：观察原发性高血压（EH）与肾实质性高血压（RH）患者肾上腺髓质素前体N端20肽（PAMP）的水平变化，探讨PAMP的降压机制。方法：用放免法测定EH与RH患者的血浆RAMP、去甲肾上腺素（NE）、肾上腺素（E）水平并计算它们之间的相关关系。结果：EH与RH患者PAMP、NE、E均较正常人明显增高，PAMP、平均动脉压（MAP）与NE有明显相关性。结论：EH及RH患者PAMP增高可能是机体维持自稳态的一种保护性代偿机制，EH与RH代尝程度有所不同。PAMP降压作用与拮抗NE、E有关。
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| 关 键 词： | 肾上腺髓质素前体N端20肽 舒血管肽 高血压 机制 病理 |
| 修稿时间： | 2000-10-20 |
The Mechanism of Proadrenomedullin N Terminal 20 Peptide in Hypertension Patients with EH and RH |
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| Zhang Zaofu,Shi Xiangyun. Fei Yuxing,et al. The Mechanism of Proadrenomedullin N Terminal 20 Peptide in Hypertension Patients with EH and RH[J]. Journal of Naval General Hospital of PLA, 2001, 14(4): 208-210 |
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| Authors: | Zhang Zaofu Shi Xiangyun. Fei Yuxing et al |
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| Affiliation: | Third Department of Cadre Wards. Naval General Hospital. Beijing 100037 |
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| Abstract: | Objective: To assess the change of proadrenomedullin N terminal 20 peptide (PAMP) in patients with essential hypertension. Methodes: The plasma concentrations of PAMP, noradrenalin (NE).adrenalin (E) in EH.RH patients were measured by radioimmunoassay (RIA). Result: The plasma concentrations of PAMP .NE..E in patinents with EH.RH were significantly higher than those of normal human, There was a positive correlation between PAMP, the mean arterial pressure (MAP) and NE. E. Conclusion: PAMP is a vasodilator peptide. The change of PAMP may be the compensatory mechanism by which the body maintains homeostasis and there was a difference between the patients with EH and RH. |
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| Keywords: | Proadrenomedullin N terminal 20 peptide (PAMP) Vasodilator peptide Hypertension Mechanism |
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